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Anti\u2010cancer drugs are developed to disrupt these processes, but they often damage healthy cells, making treatment difficult to manage safely and effectively. As the global cancer burden continues to rise, there is an urgent need for more precise and personalized approaches to detection and therapy. The study's goal is to analyze recent breakthroughs in artificial intelligence (AI), hybrid frameworks, and mathematical modeling in tumor diagnosis and treatment, examine the challenges of data\u2010driven methodologies, and highlight emerging trends with future recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>In recent years, computational methods like AI and mathematical modeling (MM) have emerged as powerful tools to address these challenges. AI techniques, including machine learning and deep learning, are increasingly used to improve early diagnosis, guide surgical planning, and predict treatment outcomes. Meanwhile, mathematical models offer valuable insights into tumor growth patterns and help optimize therapeutic strategies by simulating how tumors respond to different interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AI and MM enhance cancer detection, prediction, and treatment through precise and optimized hybrid techniques. However, challenges such as inadequate data, poor interpretability, and generalization persist, necessitating better explainable and robust models for clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This review explores the current applications of AI and MM in the field of neurosurgical oncology, emphasizing both their promising potential and the key limitations. It concludes by discussing future directions aimed at developing safer, more transparent, and individualized cancer care solutions that can ultimately improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72884","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:13:45Z","timestamp":1785140025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing Tumor Treatment Through Artificial Intelligence and Mathematical Modeling: A Comprehensive Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2990-5184","authenticated-orcid":false,"given":"Mohsin","family":"Kamran","sequence":"first","affiliation":[{"name":"Department of Mathematics Division of Science and Technology University of Education Lahore  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