{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:14Z","timestamp":1790927654446,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The increase in the use of gabapentinoids in the treatment of patients with chronic non\u2010cancer pain (CNCP) has drawn attention to the possibility of substance use disorder (SUD) due to gabapentinoids. Systematic literature reviews have provided evidence of the risk of SUD due to gabapentinoids within substance\u2010using populations. Despite concerns, prescription rates of gabapentinoids continue to increase in many countries, such as the USA, the UK, and Germany. Gabapentinoids are frequently prescribed off\u2010label for chronic pain regardless of neuropathic pain diagnosis, increasing the risk for problematic use. A recent literature review suggests that there is a potential for SUDs in CNCP, but robust data focusing specifically on this population is lacking. The present study aims to address this by investigating SUD due to gabapentinoids in a cohort of patients with CNCP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study employs an anonymous, self\u2010reported questionnaire\u2010based cross\u2010sectional design. It was conducted among CNCP patients in\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200911 general practitioner practices across two regions of Germany. A total of 93 adult patients with CNCPs who were treated with gabapentinoids were included in the final analysis. The questionnaire utilized was based on validated and established diagnostic instruments, including questions aligned with the DSM\u20105.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The data revealed a prevalence of 26.9% (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200925) for at least a mild SUD in the sample, including 5.4% with severe SUD. Logistic regression with sociodemographic, pain\u2010related, and psychological variables revealed that male sex was a statistically significant predictor of SUD due to gabapentoids (Exp(B)\u2009=\u20093.97,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05; CI: 1.40\u201311.26). This analysis is limited by sample size and self reported data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The results suggest a relevant risk for SUDs due to gabapentinoids in CNCP patients. Special care should be taken when prescribing gabapentinoids to patients with CNCP. Male sex as a predictor of SUD due to gabapentinoids should be further investigated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72888","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T21:19:53Z","timestamp":1785273593000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Predictors of Substance Use Disorder Due to Gabapentinoids in Patients With Chronic Non\u2010Cancer Pain: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0897-5201","authenticated-orcid":false,"given":"Neele","family":"Kufeld","sequence":"first","affiliation":[{"name":"Department of Human Medicine, General Practice I and Interprofessional Care, Institute of General Practice and Primary Care Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Weckbecker","sequence":"additional","affiliation":[{"name":"Department of Human Medicine, General Practice I and Interprofessional Care, Institute of General Practice and Primary Care Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"M\u00fcnster","sequence":"additional","affiliation":[{"name":"Department of Human Medicine, General Practice I and Interprofessional Care, Institute of General Practice and Primary Care Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-6990","authenticated-orcid":false,"given":"Norbert","family":"Scherbaum","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LVR\u2010University Hospital Essen, Medical Faculty University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5194-7876","authenticated-orcid":false,"given":"Michael","family":"Specka","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, LVR\u2010University Hospital Essen, Medical Faculty University of Duisburg\u2010Essen Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0866-5480","authenticated-orcid":false,"given":"Johannes","family":"Just","sequence":"additional","affiliation":[{"name":"Department of Human Medicine, General Practice I and Interprofessional Care, Institute of General Practice and Primary Care Witten\/Herdecke University Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"issue":"37","key":"e_1_2_15_2_1","first-page":"616","article-title":"The Pharmacological Therapy of Chronic Neuropathic Pain","volume":"113","author":"Binder A.","year":"2016","journal-title":"Deutsches \u00c4rzteblatt international"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s42451-019-00139-8"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.08.430"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1704633"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015620800"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0303-6"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13324"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.12358"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-021535"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614292"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.2165\/11599780-000000000-00000"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.0086"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0467-3"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.00569"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01432-7"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-013-1578-5"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002396"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39335.541782.AD"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_15_21_1","unstructured":"W.H\u00e4userandF.PetzkeDiagnostische Kriterien der Abh\u00e4ngigkeit von aus Medizinischer Indikation Verordneten Opioiden.2019. 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