{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:18Z","timestamp":1790927658177,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      The\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      allele is related to a high risk of severe cutaneous adverse drug reactions (SCARs) in patients taking certain antiepileptic drugs. However, its prevalence in the Asian population and the number of drugs linked to SCARs due to the carriage of this variant are relatively underexplored. This study sought to address these knowledge gaps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The prevalence of the\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      allele in Asian populations was estimated by using the data from the Allele Frequency Net Database. Weighted means, standard deviations, and 95% Confidence Interval (CI) were estimated for the study populations, and the chi\u2010square test was used to assess the statistical significance of variability in allele frequencies across populations. Drugs associated with SCARs due to\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      were identified from the clinical guidelines of the international pharmacogenomics (PGx) working groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      was most prevalent in South\u2010East Asia (5.6%\u2009\u00b1\u20093.1), followed by South Asia (2.1%\u2009\u00b1\u20091.5), North\u2010East Asia (0.6%\u2009\u00b1\u20090.9), and West Asia (0.01%\u2009\u00b1\u20090.05). This distribution was statistically significant (\u03c7\n                      <jats:sup>2<\/jats:sup>\n                      = 9712.5, df = 3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test). Country\u2010wise, prevalence was the highest in the Philippines (22%; 95% CI, 11.53\u201035.96%), followed by Vietnam (13.5%; 95% CI, 8.77\u201019.61%), Indonesia (11.9%\u2009\u00b1\u20091.5), Malaysia (10%\u2009\u00b1\u20094.3), Hong Kong (9.3%\u2009\u00b1\u20090.2), Thailand (8.4%\u2009\u00b1\u20090.1), Singapore (8.1%\u2009\u00b1\u20093.7), China (5.4%\u2009\u00b1\u20095.4), Taiwan (4.4%\u2009\u00b1\u20090.7), Sri Lanka (2.5%, single study), India (2.1%\u2009\u00b1\u20091.5) and South Korea (1.5%\u2009\u00b1\u20090.9). PharmGKB clinical annotations identified four drugs (carbamazepine, oxcarbazepine, lamotrigine, phenytoin) with strong evidence (Level 1\u2009A) for\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      \u2010related SCARs, though the majority of the evidence for lamotrigine came from the Han Chinese Population. International PGx working groups require or recommend preemptive\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      genotyping for at least three drugs, i.e., carbamazepine, oxcarbazepine, and phenytoin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Considering the high prevalence of the\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      in the Southeast and South Asians, and its association with drug\u2010induced SCARs, pre\u2010emptive\n                      <jats:italic>HLA\u2010B*15:02<\/jats:italic>\n                      testing may reduce SCARs substantially in this region.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72903","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:49:43Z","timestamp":1785250183000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Prevalence of the\n                    <i>HLA\u2010B*15:02<\/i>\n                    Allele in the Asian Populations: A Comprehensive Analysis Through Using AFND"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-7701","authenticated-orcid":false,"given":"Mohitosh","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Science University of Rajshahi Rajshahi Bangladesh"},{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6113-0687","authenticated-orcid":false,"given":"Murshadul Alam","family":"Murad","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Science University of Rajshahi Rajshahi Bangladesh"},{"name":"Department of Pharmacy, School of Biomedical and Life Science Khwaja Yunus Ali University Sirajganj Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2569-6377","authenticated-orcid":false,"given":"Maliheh","family":"Ershadian","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-5321","authenticated-orcid":false,"given":"Chonlaphat","family":"Sukasem","sequence":"additional","affiliation":[{"name":"Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok Thailand"},{"name":"Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC) Ramathibodi Hospital Bangkok Thailand"},{"name":"Pharmacogenomics and Precision Medicine, The Preventive Genomics &amp; Family Check\u2010up Services Center, Bumrungrad International Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14111077"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.143"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206614109"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-1578(10)60658-7"},{"key":"e_1_2_14_6_1","unstructured":"European Bioinformatics Institute. 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