{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:25Z","timestamp":1790927665005,"version":"4.1.0"},"reference-count":107,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Neuroblastoma is the most common extracranial solid tumor and contributes the most to pediatric oncology deaths worldwide. Its clinical manifestations are heterogeneous, including relapses, and the prognosis remains poor, especially for high\u2010risk patients. The principal interventions\u2014surgery, chemotherapy, and radiotherapy\u2014exacerbate the prognosis due to high morbidity and poor long\u2010term remission rates. This study attempts to integrate available information on the genetic and molecular characteristics of neuroblastoma, focusing on how the potential of precision medicine is improving neuroblastoma diagnosis and treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This review aims to compile recent literature on the genomic, transcriptomic and epigenetic studies of neuroblastoma and its treatment. The review included the most recent molecular markers for the relevant pathway, the therapeutic targets that arise from them and precision medicine approaches that incorporate AI, CRISPR, and neoantigen vaccines at various stages of clinical trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Targeted medicines such MYCN amplification, ALK mutations, and chromosomal deletions including 1p36 and 11q have revealed important genetic drivers of neuroblastoma. Early\u2010phase studies have shown encouraging reductions in tumor progression with MYCN modulators, ALK inhibitors and immunotherapies (anti\u2010GD2 antibodies, B7\u2010H3 CAR\u2010T cells). Integrating omics\u2010based markers and AI\u2010directed therapy prediction more precisely classifies risk and customizes therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Precision medicine has transformed neuroblastoma treatment by improving diagnostic specificity and therapeutic effectiveness while reducing toxicity. Among emerging strategies, ALK\u2010targeted therapies and anti\u2010GD2 immunotherapies show strong clinical potential, although further validation is still required to improve survival and quality of life in affected children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72917","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:59:24Z","timestamp":1785272364000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Precision Medicine in Neuroblastoma: Targeted Therapies and Personalized Approaches\u2014A Narrative Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2489-3631","authenticated-orcid":false,"given":"Mosammat Jannatul","family":"Mawa","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Biotechnology University of Science &amp; Technology Chittagong (USTC), Foy's Lake Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1545-5521","authenticated-orcid":false,"given":"Mohammad Shahangir","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology University of Science &amp; Technology Chittagong (USTC), Foy's Lake Chittagong Bangladesh"},{"name":"Department of Public Health Daffodil International University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2317-0948","authenticated-orcid":false,"given":"Maksudul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology University of Science &amp; Technology Chittagong (USTC), Foy's Lake Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2350-3439","authenticated-orcid":false,"given":"Munna Kumar","family":"Podder","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biotechnology Khwaja Yunus Ali University, Enayetpur Chowhali Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102964"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0804577"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.927218"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1014"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.5772\/55921"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017038"},{"key":"e_1_2_15_8_1","doi-asserted-by":"crossref","unstructured":"A. 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