{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:28Z","timestamp":1790927668407,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Hypertension (HTN) is a long\u2010term condition marked by consistently high arterial blood pressure. It is a leading contributor to cardiovascular diseases and early mortality around the globe. It increases the risk of ischemic heart disease, stroke, chronic kidney disease (CKD), and dementia. So far, several studies have been conducted, but to the authors\u2019 knowledge, there is a scarcity of similar studies done on the selected analytes in our setting, which can be an important input for the early detection of disturbance in specific parameters. So, this study aims to assess selected Clinical Chemistry analytes in hypertensive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A comparative cross\u2010sectional study was conducted at Wallaga University Referral Hospital among 105 hypertensive patients and 105 non\u2010hypertensive controls from June 2 to August 20, 2022. Participants were interviewed using structured questionnaires about their socio\u2010demographics and measured for their anthropometric characteristics. Then, five milliliters (5\u2009mL) of blood samples were collected and analyzed for fasting blood sugar (FBS), serum electrolytes, creatinine, uric acid, and lipid profiles using a Cobas c\u2010311 clinical chemistry analyzer. Data were entered into Epi Data version 4.6 and analyzed using SPSS version 26. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value of &lt;\u20090.05 was considered statistically significant at a 95% confidence level.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion<\/jats:title>\n                    <jats:p>\n                      The average age of the hypertensive and control groups was 54.69\u2009\u00b1\u200912 years and 44.82\u2009\u00b1\u200912.9 years, respectively. Hypertensive patients had significantly lower mean\u2009\u00b1\u2009SD levels of serum creatinine, total cholesterol (TC), LDL cholesterol (LDL\u2010C), HDL cholesterol (HDL\u2010C), and sodium (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to non\u2010hypertensive participants. In contrast, they had significantly higher mean\u2009\u00b1\u2009SD levels of fasting blood sugar (FBS) and triglycerides (TG). In this study, we found that the hypertensive group faced an increased risk of clinical chemistry analyte changes over time. Therefore, regular monitoring of Clinical Chemistry parameters is crucial for patients with hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72921","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:35:07Z","timestamp":1785393307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Selected Clinical Chemistry Analytes Among Hypertensive Patients at Wallaga University Referral Hospital, Nekemte, Oromia, Western Ethiopia: A Comparative Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Amanuel","family":"Hika","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry, School of Medical Laboratory Sciences, Institute of Health Sciences Wallaga University Nekemte Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sintayehu Asaye","family":"Biya","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, School of Medical Laboratory Sciences, Institute of Health Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temam Ibrahim","family":"Husen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, School of Medical Laboratory Sciences, Institute of Health Jimma University Jimma Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negesse Bokona","family":"Rufe","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Health Science Salale University Fitche Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4846-3210","authenticated-orcid":false,"given":"Hundesa Emana","family":"Urgesa","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health and Medical Sciences Haramaya University Harar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-2765-6291","authenticated-orcid":false,"given":"Bedasa","family":"Addisu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, College of Medicine and Health Sciences Debre Berhan University Debre Berhan Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0244-2"},{"key":"e_1_2_14_3_1","first-page":"3","volume-title":"Complication Prevention for Patients With Hypertension","author":"WHO","year":"2017"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IBPC.S276089"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214934"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4127-1"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4804-0"},{"issue":"1","key":"e_1_2_14_8_1","first-page":"7","article-title":"Evaluation of the Lipid Profile of Hypertensive Patients Compared to Non\u2010 Hypertensive Individuals","volume":"7","author":"Mahapatro A. 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