{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:53:55Z","timestamp":1790927635002,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["112\u20102221\u2010E\u2010006\u2010177"],"award-info":[{"award-number":["112\u20102221\u2010E\u2010006\u2010177"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["115\u20102221\u2010E\u2010006\u2010195"],"award-info":[{"award-number":["115\u20102221\u2010E\u2010006\u2010195"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>To determine whether patients with MM face higher risks of hospitalized infections and long\u2010term all\u2010cause mortality after a first fracture than non\u2010MM fracture patients at the population level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a nationwide retrospective cohort study using Taiwan National Health Insurance Research Database from 2001 to 2019. Adults with MM and non\u2010MM adults with an index hospitalized fracture were identified and matched 1:10 by propensity scores. Cox proportional\u2010hazards models and Kaplan\u2013Meier analyses compared risks of lower respiratory tract, reproductive or urinary tract, intra\u2010abdominal, and skin and soft\u2010tissue infections requiring hospitalization, as well as all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During 2001\u20132019, the incidence and age\u2010standardized incidence of MM in Taiwan were 6.0 and 5.4 per 100,000 people, respectively, and both increased over time. After propensity\u2010score matching, 303 MM patients with a first hospitalized fracture were compared with 3,030 non\u2010MM fracture patients. Compared with matched non\u2010MM patients, MM patients had significantly higher risks of lower respiratory tract infections (adjusted hazard ratio [AHR] = 2.12, 95% confidence interval [CI]: 1.72\u20132.61;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), reproductive or urinary tract infections (AHR\u2009=\u20091.40, 95% CI: 1.06\u20131.86;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.019), and all\u2010cause mortality (AHR\u2009=\u20091.98, 95% CI: 1.72\u20132.28;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). The corresponding incidence rates per 1,000 person\u2010years were also higher in MM than non\u2010MM patients for lower respiratory tract infections (237.96 vs. 60.92), reproductive or urinary tract infections (107.35 vs. 41.26), skin and soft\u2010tissue infections (28.77 vs. 15.30), and all\u2010cause mortality (271.67 vs. 84.39). These associations were generally consistent across subgroups stratified by age, sex, and fracture type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MM was associated with substantially higher risks of serious infections and death after fracture. These findings support early multidisciplinary post\u2010fracture care, including infection surveillance and prevention, in MM patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72989","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:04:32Z","timestamp":1785909872000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Increased Risk of Infections and Mortality Following Fractures in Multiple Myeloma: A Nationwide Population\u2010Based Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Ching\u2010Chi","family":"Lee","sequence":"first","affiliation":[{"name":"College of Medicine, Center of Clinical Medical Research, National Cheng Kung University Hospital National Cheng Kung University Tainan Taiwan"},{"name":"Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Yi","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Health and Welfare Policy National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Fen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Healthcare Management Yuanpei University of Medical Technology Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u2010Szu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2153-5664","authenticated-orcid":false,"given":"Kuo\u2010Yuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70442-5"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.2128"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2020-0141"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/erm.11.44"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041131"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1049909116646337"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)62051-X"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-017-0037-4"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2009.03.006"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi235"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14092278"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.107714"},{"key":"e_1_2_13_15_1","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2024.285645","article-title":"Risk of Infections in Multiple Myeloma. 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