{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:04Z","timestamp":1790927644919,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005716","name":"Babol University of Medical Sciences","doi-asserted-by":"publisher","award":["724134897"],"award-info":[{"award-number":["724134897"]}],"id":[{"id":"10.13039\/501100005716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Seasonal influenza continues to cause substantial morbidity and mortality worldwide. Identifying reliable clinical and paraclinical predictors of adverse outcomes may aid in early triage and management. This study aimed to evaluate clinical and paraclinical factors associated with prolonged hospitalization, ICU admission, and in\u2010hospital mortality in influenza\u2011positive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study analyzed 294 RT\u2010PCR\u2013confirmed influenza cases admitted to Ayatollah Rouhani Hospital (Babol, Iran) during fall\u2013winter 2022\u20132023. Demographic, clinical, and laboratory data were extracted. Key outcomes were prolonged hospital stay (&gt;\u20095 days), ICU admission, and in\u2010hospital death. Logistic regression and ROC analysis were used to identify independent predictors and cutoff values.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prolonged hospitalization occurred in 43.5% of patients, ICU admission in 8.8%, and mortality in 5.0%. In multivariate analysis, opium use (OR: 5.4), renal disease (OR: 9.27), and LDH\u2009&gt;\u20091000 (OR: 8.74) were significantly associated with longer hospital stay. LDH\u2009&gt;\u20091000 also predicted ICU admission (OR: 46.9) and mortality (OR: 21.7). Oxygen saturation &lt;\u200993% increased mortality risk (OR: 7.98). ROC analysis identified LDH\u2009\u2265\u2009633 and CRP\u2009\u2265\u200988.5 as optimal cutoffs for predicting mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Readily available markers such as LDH, CRP, liver enzymes, and oxygen saturation, which showed significant associations with prolonged hospitalization, ICU admission, or mortality in our analyses, may assist in early risk stratification of hospitalized influenza patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.72991","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T04:54:57Z","timestamp":1785992097000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Value of Clinical and Laboratory Markers in Hospitalized Influenza\u2010Positive Patients: A Retrospective Cohort Study With ROC\u2010Based Risk Stratification"],"prefix":"10.1002","volume":"9","author":[{"given":"Mohsen","family":"Daneshmand","sequence":"first","affiliation":[{"name":"Student Research Committee Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0762-5324","authenticated-orcid":false,"given":"Arefeh Ebrahimian","family":"Shiadeh","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine Golestan University of Medical Science Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzane","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemmat","family":"Gholinia","sequence":"additional","affiliation":[{"name":"Social Determinants of Health Research Center, Health Research Institute Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8599-3643","authenticated-orcid":false,"given":"Farzin","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Biology Research Center, Health Research Institute Babol University of Medical Sciences Babol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masomeh","family":"Bayani","sequence":"additional","affiliation":[{"name":"Infectious Diseases and Tropical Medicine Research Center, Health Research Institute Babol University of Medical Sciences Babol 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