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Defective efferocytosis is a sign of insufficient inflammation resolution that results in the agglomeration of secondarily necrotic macrophages and foam cells, and constitutes an advanced lesion having a necrotic lipid core, indicating plaque vulnerability. The inflammation resolution is an active, highly coordinated process governed by specialized pro\u2010resolving lipid mediators (SPMs) or immunoresolvents, a group of bioactive lipid mediators that encompass arachidonic acid\u2010derived lipoxins, omega\u20103 fatty acid eicosapentaenoic acid\u2010derived E\u2010series resolvins, docosahexaenoic acid\u2010derived D\u2010series resolvins, protectins, and maresins. These endogenously produced lipid mediators are resolution ligands functioning on distinct G\u2010protein coupled receptors, thereby exhibiting the anti\u2010inflammatory and pro\u2010resolving effects, restoring tissue homeostasis and healing. Given the involvement of lipids and their pro\u2010 and anti\u2010inflammatory derivatives in the pathogenesis of inflammatory states such as atherosclerosis, in this mini\u2010review, we have tried to give a glance at the role of immunoresolvents in illness pathophysiology and the potential for pro\u2010resolving therapeutics in atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This mini\u2010review utilized published papers available in electronic databases, including PubMed, Science Direct, and Google Scholar, to recognize pertinent sources through the following search key terms: \u201cAtherosclerosis,\u201d \u201cSPM,\u201d \u201cImmunoresolvent,\u201d \u201cLipoxin,\u201d \u201cResolvin,\u201d \u201cProtectin,\u201d and \u201cMaresin\u201d until February 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Recent investigations have shown that imbalances between pro\u2010inflammatory lipid mediators and immunoresolvents are intimately linked to failed resolution and several common human disorders, including atherosclerosis. Moreover, dysregulation of resolving inflammation in atherosclerosis and other inflammatory diseases has been delineated in recent decades.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Taken together, immunoresolvents could be regarded as new and hopeful therapeutic agents to be studied and utilized for treating atherosclerosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73012","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T04:21:16Z","timestamp":1786335676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Immunoresolvents in Atherosclerosis: A Mini\u2010Review on Their Biology and Therapeutic 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