{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:00Z","timestamp":1790927640696,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long\u2010term cardiovascular complications after COVID\u201019 are increasingly recognized, yet the protective effect of pre\u2010infection vaccination in individuals without prior cardiovascular disease (CVD) remains unclear. This study examined the association between COVID\u201019 vaccination and major cardiovascular and related outcomes up to 3 years post\u2010infection in adults without preexisting CVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective cohort analysis using the TriNetX US Collaborative Network, adults (\u2265\u200918 years) diagnosed with COVID\u201019 from March 1, 2020, to December 31, 2023, without prior CVD were identified. Patients who received \u2265\u20091 vaccine dose before diagnosis were 1:1 propensity score\u2013matched (caliper 0.1) to unvaccinated patients on 90 covariates, including demographics, comorbidities, medications, and laboratory values. Outcomes were assessed at one and 3 years. Risk ratios (RRs) with 95% confidence intervals (CIs) and\n                      <jats:italic>p<\/jats:italic>\n                      \u2010values were calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 1:1 propensity score matching, 55,752 patients were included in each cohort for the 1\u2010year analysis and 55,622 patients per cohort for the 3\u2010year analysis. Vaccination was associated with lower risk of the primary composite outcome at 1 year (RR, 0.21; 95% CI, 0.17\u20130.27;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Significant reductions were observed at 1 year for cerebrovascular disease (RR, 0.35; 95% CI, 0.27\u20130.46;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), circulatory system diseases (RR, 0.52; 95% CI, 0.50\u20130.55;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and all\u2010cause mortality (RR, 0.20; 95% CI, 0.15\u20130.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Protective effects persisted at 3 years for cerebrovascular disease (RR, 0.71; 95% CI, 0.61\u20130.82;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and circulatory system diseases (RR, 0.82; 95% CI, 0.80\u20130.85;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre\u2010infection COVID\u201019 vaccination was associated with sustained reductions in major cardiovascular events, mortality, and healthcare utilization up to 3 years post\u2010infection in adults without prior CVD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73014","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T06:15:58Z","timestamp":1786083358000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pre\u2010Infection COVID\u201019 Vaccination and Long\u2010Term Cardiovascular Outcomes in Adults Without Preexisting Cardiovascular Disease: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"given":"Abdul","family":"Qadeer","sequence":"first","affiliation":[{"name":"The University of Texas Medical Branch Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeb","family":"Khawar","sequence":"additional","affiliation":[{"name":"King Edward Medical University Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Fouad","sequence":"additional","affiliation":[{"name":"Alexandria Faculty of Medicine 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