{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:54:01Z","timestamp":1790927641657,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Methicillin\u2010resistant\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MRSA) is a significant pathogen associated with hospital\u2010acquired infections, with its global prevalence, including in Indonesia, steadily increasing. However, comprehensive data on MRSA prevalence and antimicrobial susceptibility within Indonesian hospital settings remain limited. This study aimed to assess the prevalence of MRSA and its antimicrobial susceptibility profile among clinical samples isolated from Indonesian patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional, descriptive\u2010analytic study was conducted over a 3\u2010year period (January 2022\u2013December 2024). The study population consisted of clinical specimens obtained from both inpatients and outpatients recorded at the Microbiology Laboratory. MRSA isolates were identified using standard microbiological techniques, and antimicrobial susceptibility testing was performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The multidrug resistance (MDR) profile was determined based on resistance to at least three different antibiotic classes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the clinical samples analyzed (279\n                      <jats:italic>S. aureus<\/jats:italic>\n                      ), MRSA was detected in 258 (92.47%). The highest prevalence was observed in pus samples (77.8%). MRSA and methicillin\u2010sensitive\n                      <jats:italic>S. aureus<\/jats:italic>\n                      (MSSA) isolates exhibited high susceptibility to Quinupristin\/Dalfopristin (98.1% and 100%), Linezolid (96.9% and 95.2%), Vancomycin (93% and 100%), Tigecycline (98.4% and 100%), Nitrofurantoin (98.4% and 100%), and Rifampicin (96.1% and 100%). MDR\u2010MRSA strains accounted for 55% of all MRSA isolates, a notably higher proportion compared to the 19% observed in MSSA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study highlights a notable prevalence of MRSA and MDR\u2010MRSA among clinical isolates in Semarang, coupled with a concerning level of multidrug resistance. Although certain antibiotics remain effective against MRSA, the findings emphasize the necessity for continuous surveillance and antimicrobial stewardship programs. Strengthened infection control measures and optimized antibiotic management strategies are crucial to mitigating MRSA spread and preserving effective treatment options within Indonesian healthcare settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73034","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T05:56:36Z","timestamp":1786600596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence, Antimicrobial Resistance Profile, and Multidrug Resistance of Methicillin\u2010Resistant\n                    <i>Staphylococcus aureus<\/i>\n                    (MDR\u2010MRSA) in Clinical Isolates From Indonesian Healthcare Facility: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-1395","authenticated-orcid":false,"given":"Muhammad Evy","family":"Prastiyanto","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health and Nursing Universitas Muhammadiyah Semarang Semarang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1607-5880","authenticated-orcid":false,"given":"Afifah","family":"Khairunnisa","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health and Nursing Universitas Muhammadiyah Semarang Semarang Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8284-5925","authenticated-orcid":false,"given":"Shiv Kumar","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Technology, Faculty of Health and Nursing Universitas Muhammadiyah Semarang Semarang Indonesia"},{"name":"Department of Pharmacy, Maharajgunj Medical Campus (MMC), Institute of Medicine (IOM) 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