{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:54Z","timestamp":1791186954564,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are heterogeneous hematologic malignancies with variable outcomes. Inflammatory markers from routine blood counts, including neutrophil\u2010to\u2010lymphocyte ratio (NLR), platelet\u2010to\u2010lymphocyte ratio (PLR), and monocyte\u2010to\u2010lymphocyte ratio (MLR), have emerged as potential prognostic biomarkers. This systematic review aimed to evaluate their prognostic and diagnostic significance in MDS and AML.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search of PubMed, Web of Science, and Scopus was performed from inception to June 2026. Studies evaluating NLR, PLR, or MLR in MDS or AML were included. Lymphocyte\u2010to\u2010monocyte ratio values were converted to MLR using MLR\u2009=\u20091\/LMR. Data were synthesized narratively due to heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen studies (2847 patients) met inclusion criteria. Elevated NLR, PLR, and MLR were consistently associated with shorter overall survival. NLR showed independent prognostic value in AML and higher\u2010risk MDS (HR: 1.05\u20132.136). MLR demonstrated the most consistent prognostic association (cutoffs: 0.20\u20130.67). PLR showed context\u2010dependent value (cutoffs: 22.14\u2013213.2). Only one study assessed diagnostic performance, reporting excellent discrimination for NLR (AUC\u2009=\u20090.9169) and good performance for PLR (AUC\u2009=\u20090.8312).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NLR, PLR, and MLR are accessible biomarkers that may complement risk stratification in MDS and AML. However, heterogeneity in cutoff values limits routine clinical use. Prospective standardized studies are needed to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73049","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:32:42Z","timestamp":1787808762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["\u201cPrognostic Significance of Neutrophil\u2010to\u2010Lymphocyte, Platelet\u2010to\u2010Lymphocyte, and Monocyte\u2010to\u2010Lymphocyte Ratios in Myeloid Neoplasms: A Systematic Review\u201d"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5159-5591","authenticated-orcid":false,"given":"Mahsa","family":"Dabir","sequence":"first","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Abdolbaghaei","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Nursing and Midwifery Lorestan University of Medical Sciences Khorramabad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Zoghi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Karpasand","sequence":"additional","affiliation":[{"name":"School of Nursing and Midwifery Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3773-0504","authenticated-orcid":false,"given":"Ali","family":"Maleki","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science School of Paramedical, Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/labmed-2015-0063"},{"key":"e_1_2_15_3_1","article-title":"Uncovering the Relationship Between Myelodysplastic Syndromes and Acute Myeloid Leukemia","volume":"13","author":"Yassin M. 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