{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:52Z","timestamp":1791186952156,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2021CDJYGRH\u2010014"],"award-info":[{"award-number":["2021CDJYGRH\u2010014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\u03b2\u2010lactam antibiotics stand as the most profoundly impactful classes of antibacterial agents worldwide. Their widespread application has raised safety concerns over adverse events (AEs), such as blood and lymphatic system disorders (BLSDs). This study systematically evaluated and compared BLSDs associated with \u03b2\u2010lactam antibiotics based on real\u2010world data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We reviewed the FDA Adverse Event Reporting System (FAERS) database from 2004Q1 to 2025Q1. To explore the associations between 30 FDA\u2010approved \u03b2\u2010lactam antibiotics and BLSDs, 4 disproportionality analysis algorithms were utilized, including reporting odds ratio, proportional reporting ratio, bayesian confidence propagation neural network, and multi\u2010item gamma poisson shrinker. Our analytical framework included subgroup analysis and sensitivity analysis, with the Weibull distribution applied to model the pattern of BLSDs over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The total number of reported BLSDs was 7872, accounting for 6.93% of all AEs related to \u03b2\u2010lactam antibiotics. Notably, piperacillin\/tazobactam, ceftriaxone, meropenem, cefazolin, cefepime, ceftazidime, ampicillin, oxacillin, cefotetan, and piperacillin produced strong signals of disproportionate reporting for BLSDs. Pyrexia, rash, and acute kidney injury emerged as the most frequently reported concurrent AEs. At the designated medical event level, several \u03b2\u2010lactam antibiotics were found to be associated with agranulocytosis, hemolytic anemia, immune thrombocytopenia, pancytopenia, and other hematological AEs. With respect to the time\u2010to\u2010onset patterns, ceftriaxone, meropenem, and ceftazidime were classified as early failure modes, whereas cefepime, cefotetan, oxacillin, and piperacillin were categorized as wearout failure modes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study revealed a notable association between \u03b2\u2010lactam antibiotics and BLSDs, underscoring the importance of blood tests in clinical practice when \u03b2\u2010lactam antibiotics are prescribed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73061","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:11:22Z","timestamp":1787739082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Disproportionality Analysis of \u03b2\u2010lactam Antibiotic Related Blood and Lymphatic System Disorders Based on the FDA Adverse Event Reporting System Database"],"prefix":"10.1002","volume":"9","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital Chongqing China"},{"name":"Department of Pharmacy The Second Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9583-4647","authenticated-orcid":false,"given":"Zongwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Chongqing University Cancer Hospital Chongqing 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