{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:56:20Z","timestamp":1791186980268,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n New respiratory syncytial virus (RSV) preventative programs are launching globally. Our Australian jurisdiction implemented RSV monoclonal antibody provision via pediatric and perinatal hospitals for highest risk neonates and infants. The aim of this study was to monitor the implementation and utilization of nirsevimab and palivizumab in a cohort of infants at increased risk who were program recipients in Victorian hospitals in 2024 and provide evidence and operational context for future programs.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n In this observational cohort study, suitable participants at each site were identified by checking the drug administration records for receipt of nirsevimab and\/or palivizumab. Follow\u2010up of all infants was via the hospital electronic medical record (EMR), with relevant administration information as well as any subsequent respiratory encounters (defined by testing for respiratory pathogens) at either Monash Children's Hospital or the Royal Children's Hospital, Melbourne. This study was descriptive and exploratory, and no formal effectiveness or comparative analyses were undertaken.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n In total, 430 infants received RSV preventatives at five hospital sites throughout Victoria. In total, 54% of infants who received RSV preventatives were premature (<\u200937 weeks gestation); 45% were <\u200932 weeks gestation and four infants (2 pre\u2010term; 2 term) experienced breakthrough infection.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Without a national program combining maternal and infant preventatives, hospital\u2010level targeted programs can protect infants at highest risk of severe RSV and reduce admissions; we recommend biopharmaceutical support for these targeted initiatives over large population\u2010wide programs that have not met cost\u2010effectiveness criteria\u2014this 2024 approach informed Australia's 2025 RSV program. Findings will inform ongoing RSV special\u2010risk initiatives.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hsr2.73066","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:12:36Z","timestamp":1787746356000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["RSV Monoclonal Antibody Implementation for At\u2010Risk Infants: Victoria, Australia's 2024 Experience"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6938-1751","authenticated-orcid":false,"given":"Jane","family":"Tuckerman","sequence":"first","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Allergy and Lung Health Unit, School of Population and Global Health University of Melbourne Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5455-957X","authenticated-orcid":false,"given":"Daryl R.","family":"Cheng","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillian","family":"Hunter","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunity Monash Children's Hospital Melbourne Clayton Victoria Australia"},{"name":"Department of Paediatrics Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Elia","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Hearn","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepali","family":"Verma","sequence":"additional","affiliation":[{"name":"Royal Children's Hospital Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Neonatal Services Royal Women's Hospital Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Infection and Immunity Monash Children's Hospital Melbourne Clayton Victoria Australia"},{"name":"Department of Paediatrics Monash University Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel W.","family":"Crawford","sequence":"additional","affiliation":[{"name":"Murdoch Children's Research Institute Parkville Victoria Australia"},{"name":"Royal Children's Hospital Melbourne Victoria Australia"},{"name":"Department of Paediatrics University of Melbourne Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2021-322435"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2025-328666"},{"key":"e_1_2_15_4_1","unstructured":"Queensland Government: Queensland Health \u201cQueensland Paediatric Respiratory Syncytial Virus Prevention Program: Queensland Government \u201d cited May2024 https:\/\/www.health.qld.gov.au\/clinical-practice\/guidelines-procedures\/diseases-infection\/immunisation\/paediatric-rsv-prevention-program."},{"key":"e_1_2_15_5_1","unstructured":"Government of Western Australia Department of Health \u201cRespiratory Syncytial Virus (RSV) immunisation WA: Government of Western Australia Department of Health \u201d cited May2024 https:\/\/www.health.wa.gov.au\/Articles\/N_R\/Respiratory-syncytial-virus-RSV-immunisation."},{"key":"e_1_2_15_6_1","unstructured":"New South Wales Government: NSW Health \u201cNSW Health RSV (Respiratory Syncytial Virus) Vulnerable Babies Program: NSW Health \u201d cited May2024 https:\/\/www.health.nsw.gov.au\/immunisation\/Pages\/respiratory-syncytial-virus.aspx."},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2011.02219.x"},{"key":"e_1_2_15_8_1","unstructured":"Royal Children's Hospital Immunisation Service \u201cRCH Immunisation Service Biannual Reports Melbourne Royal Children's Hospital \u201d cited2022 https:\/\/www.rch.org.au\/immunisation\/education-resources\/."},{"key":"e_1_2_15_9_1","unstructured":"Australian Government Department of Health and Aged Care \u201cMinister for Health and Aged Care Press Conference 19 January 2025 \u201d cited2024 https:\/\/www.health.gov.au\/ministers\/the-hon-mark-butler-mp\/media\/minister-for-health-and-aged-care-press-conference-19-january-2025."},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52655"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2025.106466"},{"key":"e_1_2_15_12_1","volume-title":"Immunisation Service\u2014Palivizumab Report\u20142023","author":"Royal Children's Hospital Immunisation Service","year":"2023"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.52671"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.73066","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.73066","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.73066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:42:19Z","timestamp":1791186139000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.73066"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":12,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/hsr2.73066"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.73066","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"assertion":[{"value":"2025-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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