{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:52:27Z","timestamp":1792155147739,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004748","name":"Mashhad University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004748","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Vitamin D, a fat\u2010soluble vitamin, has various vital roles in physiological processes. Recent evidence suggests that optimal vitamin D levels may be associated with improved immune function and reduced systemic inflammation. The present study aims to evaluate associations between serum vitamin D levels and various hematological inflammatory indices in participants of the MASHAD cohort study, Mashhad, Iran.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study was designed as a cross\u2010sectional analysis conducted within the framework of phase I of the MASHAD cohort study. Participants (aged \u2265\u200918 years old and signed an informed consent) were recruited from a defined population, ensuring the representativeness of the sample for evaluation of potential association between serum vitamin D levels and hematological inflammatory indices including Red Cell Distribution Width (RDW\u2010CV), high\u2010sensitivity C\u2010reactive protein (hs\u2010CRP), systemic immune\u2010inflammation index (SII), platelet\u2010to\u2010lymphocyte ratio (PLR), Neutrophil\u2010to\u2010Lymphocyte Ratio (NLR), Mean Platelet Volume (MPV), and Platelet Distribution Width (PDW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 458 participants were included in the current study, comprising 229 males and 229 females. Serum vitamin D had weak correlation with hs\u2010CRP (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.02), SII (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.01), PLR (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.05), NLR (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u20090.01), PDW (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.05), and RDW\u2010CV (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.04). For males, no significant differences were observed in RDW\u2010CV, PDW, MPV, NLR, or PLR across the vitamin D quartiles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05 for all comparisons). In contrast, among female participants, significant differences in PDW (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) between quartile groups 1 and 4, and marginal significance between quartile 1 and 3 for RDW (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.062) were observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current findings revealed a weak association between serum vitamin D concentrations and inflammatory indicators. Among hematological parameters, gender\u2010based differences were observed, with PDW and RDW levels significantly varying between vitamin D quartiles in women.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73142","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:43:02Z","timestamp":1790757782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Serum Vitamin D Level and Hematological Inflammatory Indices in Participants of the MASHAD Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2695-3072","authenticated-orcid":false,"given":"Abbas","family":"Mohtashamian","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran"},{"name":"Student Research Committee Mashhad University of Medical Sciences Mashhad 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