{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:56:17Z","timestamp":1791186977356,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review aimed to assess the clinical and experimental utility of three\u2010dimensional (3D) printing in medical and dental applications, with a focus on its impact on surgical precision, procedural efficiency, and patient\u2010centered results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis were conducted following PRISMA 2020 guidelines. Database searches identified 481 records, of which 15 studies were included in the review; eight contributed to one or more meta\u2010analyses. Quantitative analysis assessed operative time and intraoperative blood loss using mean differences with random\u2010effects models. Study quality was evaluated using NOS, Cochrane RoB 2, and ROBINS\u2010I tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen studies were included; eight contributed to at least one meta\u2010analysis. At the study level, 5 of 7 comparative studies (71.4%) favored 3D printing for accuracy, fit, alignment, or planning; all 10 studies reporting procedural or operative time favored it; and 4 of 7 (57.1%) reported better patient\u2010centered or functional outcomes. Random\u2010effects models showed no statistically significant reduction in operative time (MD, \u221224.88\u2009min; 95% CI, \u221262.45 to 12.70;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.19;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009100%) and significantly lower intraoperative blood loss (MD, \u221261.55\u2009mL; 95% CI, \u221282.62 to \u221240.49;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200983%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Available evidence suggests that 3D printing may improve procedural precision, patient\u2010specific planning, and selected clinical outcomes; however, extreme heterogeneity and limited outcome\u2010specific evidence preclude broad generalization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73163","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:00:01Z","timestamp":1788325201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Efficacy and Accuracy of 3D\u2010Printed Medical Devices: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5071-9860","authenticated-orcid":false,"given":"Vishnu Priya","family":"Veeraraghavan","sequence":"first","affiliation":[{"name":"Center of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-5708","authenticated-orcid":false,"given":"Krishna Mohan","family":"Surapaneni","sequence":"additional","affiliation":[{"name":"Departments of Biochemistry, Medical Education Panimalar Medical College Hospital &amp; Research Institute Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-8289","authenticated-orcid":false,"given":"Seyed Ali","family":"Mosaddad","sequence":"additional","affiliation":[{"name":"Department of Research Analytics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences Saveetha University Chennai India"},{"name":"Department of Conservative Dentistry and Prosthodontics, Faculty of Dentistry Complutense University of Madrid Madrid Spain"},{"name":"Department of Prosthodontics, School of Dentistry Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2023.105930"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-016891"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12315"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stlm.2024.100149"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1302\/2046-3758.1012.BJR-2021-0288.R2"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-20-00230"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41205-016-0009-5"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1504-6"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/prosthesis6040064"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma13183970"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17010140"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2025.107195"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2022.105976"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tipsro.2022.06.001"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.37349\/emed.2023.00200"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-016-0236-4"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43465-020-00263-8"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_13_21_1","volume-title":"The Newcastle\u2010Ottawa Scale (NOS) for Assessing the Quality of Non\u2010Randomised Studies in Meta\u2010Analyses","author":"Wells G. 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