{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:37Z","timestamp":1791186937639,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human immunodeficiency virus (HIV) remains a major public health challenge in sub\u2010Saharan Africa, including Ethiopia. Adults living with HIV are at increased risk of liver\u2010related complications, poor treatment outcomes, and suboptimal virological control, particularly when adherence to antiretroviral therapy (ART) is inadequate. Patient\u2010centered education has emerged as a promising strategy for improving treatment adherence, self\u2010management, and health outcomes among individuals with chronic diseases. However, evidence on the effect of patient\u2010centered education on HIV virological outcomes among adults living with HIV remains limited, particularly in resource\u2010constrained settings such as North\u2010West Ethiopia. Furthermore, limited evidence exists regarding the feasibility and acceptability of structured educational interventions tailored to this vulnerable population. This pilot quasi\u2010experimental study therefore aims to assess the effect of a patient\u2010centered education intervention on HIV virological outcomes among adults living with HIV in North\u2010West Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the feasibility and preliminary effectiveness of a patient\u2010centered educational intervention on HIV virological outcomes, medication adherence, and HIV\u2010related knowledge among 120 adult people living with HIV\u2013HBV co\u2010infection receiving ART in North\u2010West Ethiopia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Analysis<\/jats:title>\n                    <jats:p>\n                      This pilot quasi\u2010experimental study will employ non\u2010randomized intervention and comparison groups with baseline and 6\u2010month follow\u2010up assessments. A total of 120 participants (60 per group) will be enrolled from selected hospitals in North\u2010West Ethiopia. Participants in the intervention group will receive a structured patient\u2010centered education program integrated into routine ART services, while the comparison group will continue receiving standard care. Quantitative data will be entered into EpiData version 4.6 and analyzed using STATA version 18. Descriptive statistics will summarize baseline characteristics. Baseline differences between groups will be assessed using chi\u2010square tests for categorical variables and independent t\u2010tests or non\u2010parametric equivalents for continuous variables. The primary outcome will be the change in log\u2010transformed HIV viral load (log\n                      <jats:sub>10<\/jats:sub>\n                      copies\/mL) from baseline to the end of the 6\u2010month follow\u2010up period. The intervention effect will be evaluated using paired t\u2010tests, difference\u2010in\u2010differences analysis, and multivariable linear regression while adjusting for potential confounders, including age, sex, educational status, baseline viral load, duration of ART, and medication adherence. Virological suppression, defined as HIV viral load &lt;\u20091000 copies\/mL, will be assessed as a secondary clinical outcome. Secondary outcomes will include medication adherence, HIV\u2010HBV\u2010related knowledge, self\u2010management practices, and retention in care. Statistical significance will be declared at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05. A qualitative study will be conducted at the end of the intervention period to assess the feasibility, acceptability, and implementation potential of the intervention. Qualitative data will be collected through focus group discussions with adult people live with HIV, in\u2010depth interviews with healthcare providers, and key informant interviews with hospital leaders and program managers. Audio\u2010recorded interviews will be transcribed verbatim and analyzed using directed thematic analysis with MAXQDA version 20.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>International Trial Registration Number<\/jats:title>\n                    <jats:p>The intervention protocol was registered on 15 November 2025 with the Pan African Clinical Trials Registry under identification number PACTR202512648125852.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73167","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:03:17Z","timestamp":1788238997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protocol for a Pilot Quasi\u2010Experimental Study on the Effect of Patient\u2010Centered Education on HIV Virological Outcomes Among Adult People Live With HIV\u2010HBV Co\u2010Infection in North\u2010West Ethiopia: Protocol for a Pilot Quasi\u2010Experimental Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0290-9025","authenticated-orcid":false,"given":"Mequanente","family":"Dagnaw","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Public Health University of Gondar Gondar Ethiopia"},{"name":"Department of Medical Biotechnology, Institute of Biotechnology University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-8551","authenticated-orcid":false,"given":"Destaw Fetene","family":"Teshome","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Public Health University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilahun Bizuayehu","family":"Demass","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1146-3399","authenticated-orcid":false,"given":"Abebaw Gebyehu","family":"Worku","sequence":"additional","affiliation":[{"name":"Reproductive Health Department, Institute of Public Health, College of Medicine and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"Joint United Nations Programme on HIV\/AIDS (UNAIDS). 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