{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:32Z","timestamp":1791186932161,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Major adverse cardiac and cerebrovascular events (MACCE) are significant complications following percutaneous coronary intervention (PCI). Identifying the predictors of these events can aid in improving outcomes, especially in specific populations such as the Iranian cohort. This study aims to investigate the incidence and predictors of short\u2010 and long\u2010term MACCE after PCI in patients from the National Persian Registry of Cardiovascular Disease (N\u2010PROVE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cohort study involving 1921 patients who underwent PCI for acute coronary syndrome at Razi Hospital, Birjand, Iran. Data on demographics, medical history, procedural details, and follow\u2010up outcomes were collected. The primary endpoint was the occurrence of MACCE, including all\u2010cause mortality, myocardial infarction (MI), cerebrovascular accident (CVA), and target\u2010vessel revascularization (TVR), at 1\u2010, 6\u2010, and 12\u2010months post\u2010PCI. Predictors of MACCE were identified using univariate and multivariate Cox proportional hazards models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MACCE occurred in 8.5% of patients at 1 month, 13.7% at 6 months, and 17.9% at 12 months post\u2010PCI. Independent predictors of MACCE included age \u2265\u200975 years, female sex, diabetes mellitus (DM), multi\u2010vessel disease (MVD), and poor TIMI flow. Multivariate analysis confirmed DM (HR 1.52, 95% CI 1.07\u20132.23), 2VD (HR 1.59, 95% CI 1.05\u20132.42), 3VD (HR 1.55, 95% CI 1.01\u20132.75), and TIMI flow 0\u2010I (HR 2.31, 95% CI 1.53\u20133.49) as significant predictors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study highlights key predictors of MACCE, particularly age, sex, DM, and TIMI flow. These findings underscore the need for tailored interventions for high\u2010risk groups, especially elderly patients and those with MVD, to improve long\u2010term outcomes following PCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73272","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:14:08Z","timestamp":1789622048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Short\u2010 and Long\u2010Term Major Adverse Cardiac and Cerebrovascular Events (MACCE) After Percutaneous Coronary Intervention: A Cohort Study on the Data of National Persian Registry of Cardiovascular Disease (N\u2010PROVE)"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9496-9343","authenticated-orcid":false,"given":"Nahid","family":"Azdaki","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran"},{"name":"Clinical Research Development Unit, Razi Hospital Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9128-6424","authenticated-orcid":false,"given":"Seyed Ali Moezi","family":"Bady","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6204-4514","authenticated-orcid":false,"given":"Toba","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8618-1778","authenticated-orcid":false,"given":"Marzieh","family":"Azimizadeh","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases Research Center Birjand University of Medical Sciences Birjand Iran"},{"name":"Yazd Cardiovascular Research Center, Non\u2010communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-5295","authenticated-orcid":false,"given":"Hamidreza","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Non\u2010communicable Diseases Research Institute Shahid Sadoughi University of Medical Sciences Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Khosravi","family":"Farsani","sequence":"additional","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"},{"name":"Iranian Network of Cardiovascular Research Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6828-2169","authenticated-orcid":false,"given":"Nizal","family":"Sarrafzadegan","sequence":"additional","affiliation":[{"name":"Iranian Network of Cardiovascular Research Tehran Iran"},{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0946-3354","authenticated-orcid":false,"given":"Maryam","family":"Boshtam","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-8500","authenticated-orcid":false,"given":"Pedro Manuel","family":"Marques\u2010Vidal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Internal Medicine Lausanne University Hospital and University of Lausanne Office BH10\u2010642, 46 Rue du Bugnon Lausanne 1011 Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"issue":"4","key":"e_1_2_14_2_1","first-page":"82","article-title":"A Review of the Association Between Demographic, Laboratory, and Angiographic Findings and Major Cardiovascular Events in Patients Undergoing Elective Percutaneous Coronary Interventions","volume":"21","author":"Alemzadeh\u2010Ansari M. 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