{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:55:32Z","timestamp":1791186932246,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","award":["99\u20102\u2010101\u201048955"],"award-info":[{"award-number":["99\u20102\u2010101\u201048955"]}],"id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Previous research investigated the connection between lichen planus (LP) and thyroid disorders due to their autoimmune characteristics; however, the correlation remains unclear. This study investigates the relationship between thyroid disorders and specific subtypes of LP, particularly cutaneous lichen planus (CLP) and lichen planopilaris (LPP), to determine the need for thyroid screening in LP patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case\u2010control study at Razi Hospital's skin clinic (2023\u20132024) involved 70 LP patients and 70 controls. A dermatologist confirmed the diagnosis via clinical evaluation and biopsy. Medical histories, medication, and BMI were collected. Serological tests for thyroid disorders were conducted, and patients were categorized accordingly. Data analysis was performed using SPSS version 22.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study shows a significant link between LP and thyroid disorders (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), consistent across LP subtypes (CLP and LPP). LP patients had higher TSH (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and anti\u2010TPO antibody levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001), while free T4 levels were lower but not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.38). Anti\u2010TPO antibody levels were significantly elevated in both LP subtypes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01 in CLP and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002 in LPP) compared to controls. Age, gender, BMI, and T3 levels did not significantly correlate with LP. Longer LP duration was associated with higher TSH levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is a significant relationship between LP and thyroid disorders, particularly hypothyroidism. These findings advocate for regular thyroid function monitoring in LP patients to facilitate early detection and management of thyroid issues.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73273","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:00:42Z","timestamp":1789804842000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Relationship Between Lichen Planus and Thyroid Disorders in an Iranian Population: A Case\u2010Control Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6790-7633","authenticated-orcid":false,"given":"Safoura","family":"Shakoei","sequence":"first","affiliation":[{"name":"Department of Dermatology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences (TUMS) Tehran Iran"},{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-2164","authenticated-orcid":false,"given":"Helya","family":"Bolouki Azari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences (TUMS) Tehran Iran"},{"name":"Sleep Breathing Disorders Research Center (SBDRC) Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arman","family":"Soleimany","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences (TUMS) Tehran Iran"},{"name":"School of Medicine Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adnan","family":"Mastalizadeh","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Daneshpazhooh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Razi Hospital Tehran University of Medical Sciences (TUMS) Tehran Iran"},{"name":"Autoimmune Bullous Diseases Research Center, Department of Dermatology Tehran University of Medical Sciences (TUMS) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/742826"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70241-S"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1103641"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.1987.tb00480.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/0001555571242244"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2019.3797"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.04.027"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12031"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12850"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2006.08.024"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12202"},{"issue":"1","key":"e_1_2_11_13_1","first-page":"38","article-title":"Evaluation of the Association Between Oral Lichen Planus and Hypothyroidism: A Retrospective Comparative Study","volume":"17","author":"Lavaee F.","year":"2016","journal-title":"Journal of Dentistry (Shiraz, Iran)"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2017.vol31.0010"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.967988"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.14127"},{"key":"e_1_2_11_17_1","first-page":"510","article-title":"The Correlation Between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population","volume":"18","author":"Piloni S.","year":"2023","journal-title":"European Journal of Dentistry"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad235"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12010077"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1984.tb06629.x"},{"issue":"3","key":"e_1_2_11_21_1","first-page":"1","article-title":"Characterization of Mononuclear Cells of Inflammatory Infiltrates in Oral Tissues. A Histochemical and Immunohistochemical Study of Labial Salivary Glands in Sj\u00f6gren's Syndrome and of Oral Lesions in Systemic Lupus Erythematosus and in Lichen Planus","volume":"84","author":"Kilpi A.","year":"1988","journal-title":"Proceedings of the Finnish Dental Society. Suomen Hammaslaakariseuran Toimituksia"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0904-2512.2001.10063.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/ETJ-21-0024"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-17-0262"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00310"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00330"},{"issue":"2","key":"e_1_2_11_27_1","first-page":"71","article-title":"Coexistence of Thyroid Disease and Oral Lichen Planus in a Colombian Population","volume":"32","author":"Amato\u2010Cuartas P. 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