{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:46:13Z","timestamp":1792172773167,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive \u03b2\u2010cell dysfunction aggravated by chronic low\u2010grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This narrative review was conducted through systematic database searches (PubMed, Scopus, Web of Science, Google Scholar) using predefined keywords related to myokines, type 2 diabetes, \u03b2\u2010cell survival, and triceps brachii. Publications from 2010 to 2025 were included based on scientific relevance and thematic suitability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among known myokines, irisin, FGF21, IL\u20106, and IL\u201015 demonstrate beneficial actions on glucose homeostasis, insulin sensitivity, and \u03b2\u2010cell survival. Evidence suggests that muscle fiber type composition may influence myokine secretion patterns, with type II fibers, predominant in the triceps brachii, producing distinct bioactive profiles. Notably, angiogenin and osteoprotegerin, associated with type II fiber activity, display cytoprotective effects on pancreatic \u03b2\u2010cells by reducing oxidative stress, modulating inflammation, and inhibiting apoptosis. Conflicting data exist, as the type II fiber secretome can also be pro\u2010inflammatory under metabolic stress conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Triceps\u2010targeted resistance exercises could represent a promising non\u2010pharmacological strategy to enhance protective myokine release, complementing conventional diabetes management. Nevertheless, most available data derive from preclinical studies, and translational evidence in humans remains scarce. Future research should prioritize longitudinal and interventional studies to validate these findings, assess interindividual variability, and explore therapeutic applications of type II fiber\u2010associated myokines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73278","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:50:36Z","timestamp":1790139036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Role of Triceps Muscle Fiber\u2010Specific Myokines in Pancreatic \u03b2\u2010Cell Protection: Implications for Type 2 Diabetes: A Narrative Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8547-3153","authenticated-orcid":false,"given":"Christian","family":"Tague","sequence":"first","affiliation":[{"name":"Department of Research Medical Research Circle (MedReC) Goma DR Congo"},{"name":"Faculty of Medicine 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