{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:41:02Z","timestamp":1792406462621,"version":"4.4.0"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT MARVEL (PTDC\/SAU\u2010PUB\/4018\/2021)"],"award-info":[{"award-number":["FCT MARVEL (PTDC\/SAU\u2010PUB\/4018\/2021)"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["FCT GHTM\u2010UID\/04413\/2020"],"award-info":[{"award-number":["FCT GHTM\u2010UID\/04413\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LA\u2010REAL\u2010LA\/P\/0117\/2020"],"award-info":[{"award-number":["LA\u2010REAL\u2010LA\/P\/0117\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sickle cell anemia (SCA) may influence malaria susceptibility and clinical outcomes in endemic regions. However, the interaction between hemoglobin genotypes and malaria severity remain poorly defined in endemic African settings, particulary in Angola, where SCA and malaria impose a substantial public health burden. Herein, we investigate associations between hemoglobin genotypes and clinical outcomes among malaria patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective cohort study conducted with 252 malaria patients in Luanda, the capital city of Angola, a sub\u2010Saharan African country. Association between hemoglobin genotypes and demographic, geographic, parasitological, and clinical variables were assessed in relation to malaria outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HbAA was predominant (75.0%), followed by HbAS (16.7%) and HbSS (8.3%). Mean age did not differ significantly across genotypes (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.289), whereas gender distribution differed significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), with a high proportion of females among HbAS individuals (73.8%). No significant differences were observed across genotypes in residence, ABO blood group, or parasitemia levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Clinical outcomes differed significantly by hemoglobin genotype (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016), with lower discharge rates (57.1%) and higher mortality (19.0%) among HbSS patients. Unfavorable outcomes were more frequent among adults with HbS (OR: 1.59), males (OR: 2.03), peri\u2010urban residents (OR\u2009=\u20092.2), or blood group O (OR\u2009=\u20092.16), although no statistical significance was observed (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&gt;\u20090.05). Among HbAA patients, low parasitaemia was significantly associated with favorable outcomes (OR\u2009=\u20090.35,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that HbSS may be associated with increased malaria morbidity and mortality in Angola. Further studies incorporating molecular characterization of malaria parasites are needed to elucidate clinical trajectories and parasite\u2010host interactions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73288","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:15:34Z","timestamp":1790154934000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Sickle Cell Hemoglobin Genotypes on Clinical Outcomes Among\n                    <i>Plasmodium falciparum<\/i>\n                    Malaria Patients in Luanda, Angola"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1232-0119","authenticated-orcid":false,"given":"Cruz S.","family":"Sebasti\u00e3o","sequence":"first","affiliation":[{"name":"Centro Nacional de Investiga\u00e7\u00e3o Cient\u00edfica (CNIC) Luanda Angola"},{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Angola (CISA) Instituto Nacional de Investiga\u00e7\u00e3o em Sa\u00fade (INIS) Luanda Angola"},{"name":"Global Health and Tropical Medicine, GHTM, LA\u2010REAL Instituto de Higiene e Medicina Tropical, IHMT, Universidade NOVA de Lisboa Lisboa Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Ekundi\u2010Valentim","sequence":"additional","affiliation":[{"name":"Universidade Rainha Nginga a Mbande (URNM) Malanje Angola"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Cassinela","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investiga\u00e7\u00e3o Cient\u00edfica (CNIC) Luanda Angola"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2341-9133","authenticated-orcid":false,"given":"Euclides","family":"Sacomboio","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias de Sa\u00fade (ICISA) Universidade Agostinho Neto (UAN) Luanda Angola"},{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o em Ci\u00eancias de Sa\u00fade (LAICISA) Luanda Angola"},{"name":"Universidade Greg\u00f3rio Semedo (UGS) Luanda Angola"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"World Malaria Report","author":"World Health Organisation 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