{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:54:20Z","timestamp":1792158860442,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Gynecological cancers are a major global health burden, with ovarian, uterine, and cervical cancers being the most common types. Despite rising national incidence rates, recent comprehensive data for Gilan Province remain limited. This study investigated the incidence trends of gynecological cancers in Gilan Province, Northern Iran, from 2014 to 2018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A repeated cross\u2010sectional analysis was conducted using data from the National Cancer Registry and Guilan University of Medical Sciences. Newly diagnosed cases of gynecological cancers were identified and classified according to ICD\u2010O\u20103. Statistical analyses included descriptive statistics, one\u2010way ANOVA for age group comparisons, and joinpoint regression to evaluate trends.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1058 cases were analyzed. The overall incidence rate rose by 98.2% over 5 years from 2014 to 2018, increasing from 10.72 to 21.25 cases per 100,000 individuals. The mean age of patients was 55.43\u2009\u00b1\u20093.63 years, showing no significant variation over time. Ovarian cancer was the most common type of gynecological cancer (42%), followed by corpus uteri (29.5%) and cervical cancer (15.2%), with 5\u2010year incidence rates of 35.15, 24.7, and 12.73 cases per 100,000 individuals, respectively. Joinpoint regression suggested significant annual increases in both crude (APC\u2009=\u200919.19%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.040) and age\u2010adjusted rates (APC\u2009=\u200922.22%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). While the cumulative 5\u2010year incidence of gynecological cancers was 83.78, significant geographic disparities were observed; Bandar\u2010e Anzali exhibited the highest rate (148.57), followed by Astaneh\u2010ye Ashrafiyeh (103.88), whereas Talesh reported the lowest (56.66).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of gynecological cancers in Gilan province almost doubled during the study period, highlighting a substantial public health concern linked to long\u2010term burden and mortality rates. Interventions should prioritize community\u2010wide education, timely referrals, expanded access to diagnostic services, and enhanced awareness of early symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73296","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:53:43Z","timestamp":1790837623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of Gynecological Cancers Is Rising in Northern Iran: A Population\u2010Based, Serial Cross\u2010Sectional Joinpoint Regression Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8767-0446","authenticated-orcid":false,"given":"Mohammad","family":"Amouzadeh\u2010Lichahi","sequence":"first","affiliation":[{"name":"Student Research Committee, School of Medicine, Anzali International Campus Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3583-278X","authenticated-orcid":false,"given":"Sahand","family":"Karimzadhagh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Clinical Research Development Unit of Ghaem Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9925-4195","authenticated-orcid":false,"given":"Nooshin","family":"Zaresharifi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4285-6486","authenticated-orcid":false,"given":"Azadeh","family":"Jafari","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Guilan university of medical sciences Rasht Iran"},{"name":"Department of Obstetrics and Gynecology, Al\u2010Zahra Hospital Reproductive Health Research Center Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5248-9372","authenticated-orcid":false,"given":"Paridokht","family":"Karimian","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Guilan university of medical sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4875-6133","authenticated-orcid":false,"given":"Maryam","family":"Jafari","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine, Anzali International Campus Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamreza","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Guilan Cancer Registry Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-0887","authenticated-orcid":false,"given":"Mohammad Ali","family":"Yazdanipour","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center Poursina Hospital Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"309","article-title":"Incidence and Mortality of Various Cancers in Iran and Compare to Other Countries: A Review Article","volume":"47","author":"Farhood 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