{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:51:57Z","timestamp":1791985917043,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Chronic obstructive pulmonary disease (COPD) is frequently complicated by acute hypercapnic respiratory failure (AHRF) requiring non\u2010invasive ventilation (NIV). Early identification of NIV failure is important, as delayed recognition may worsen outcomes. This study evaluated the predictive utility of the 1\u2010h HACOR score for early identification of NIV failure in COPD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective observational study was conducted at the National Institute of Diseases of the Chest and Hospital, Dhaka, from May 2022 to September 2023. Ninety\u2010two patients of acute exacerbations of COPD with AHRF were purposively enrolled. Clinical parameters and HACOR scores were recorded at baseline and 1\u2009h after NIV initiation. NIV failure was defined as death or need for intubation, classified as early (&lt;\u200948\u2009h) or late (\u2265\u200948\u2009h).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      About 13.1% patients experienced NIV failure. The HACOR score decreased significantly at 1\u2009h of NIV initiation in the success group (8.16\u2009\u00b1\u20094.52 to 3.38\u2009\u00b1\u20092.93;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) but remained persistently high in the failure group. A HACOR cut\u2010off value of \u2265\u20096 at 1\u2009h predicted NIV failure with 91.67% sensitivity, 83.75% specificity, while \u2265\u20098 reliably identifies patients at high risk of early NIV failure with 100% sensitivity and 89.29% specificity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The HACOR score was a simple and reliable bedside tool for early prediction of NIV failure in patients with acute exacerbation of COPD complicated by AHRF. Its routine use may facilitate timely reassessment and escalation of respiratory support, although larger multicenter studies are needed for further validation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73312","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:39:34Z","timestamp":1790735974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Accuracy of the 1\u2010h HACOR Score for Identifying Non\u2010Invasive Ventilation Failure in COPD Patients With Acute Hypercapnic Respiratory Failure: A Prospective Observational Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7025-6246","authenticated-orcid":false,"given":"Md. Joynal","family":"Abedin","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Chittagong Medical College Chittagong Bangladesh"},{"name":"Department of Respiratory Medicine National Institute of Diseases of the Chest &amp; Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Zakir Hossain","family":"Sarker","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Institute of Diseases of the Chest &amp; Hospital Dhaka Bangladesh"},{"name":"Department of Respiratory Medicine Labaid Cardiac Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ferdous","family":"Wahid","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Institute of Diseases of the Chest &amp; Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mahbub","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Institute of Diseases of the Chest &amp; Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mirazur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine National Institute of Diseases of the Chest &amp; Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9021-7742","authenticated-orcid":false,"given":"S. M.","family":"Masuduzzaman","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kushtia Medical College Hospital Kushtia Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_2_15_2_1","unstructured":"World Health Organization Chronic Obstructive Pulmonary Disease (COPD)(World Health Organization 2024) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chronic-obstructive-pulmonary-disease-(copd)."},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2009.02.002"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/17476348.2015.1046438"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201701-0218PP"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200707-088ET"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.153114"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004104"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-1207"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-001-1114-4"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-015-0139-3"},{"issue":"20","key":"e_1_2_15_12_1","first-page":"3855","article-title":"Predictors of Outcome for Patients With Severe Respiratory Failure Requiring Non Invasive Mechanical Ventilation","volume":"19","author":"Conti V.","year":"2015","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S39403"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.894191"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000251821.44259.F3"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc4923"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31818699f6"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-008-0637-z"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2475-6"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13103"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12184"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4601-3"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-019-0585-9"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2020.08.008"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00085304"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.10.819"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-04060-7"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-019-0892-9"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.73312","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.73312","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.73312","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:26:29Z","timestamp":1791984389000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.73312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/hsr2.73312"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.73312","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"assertion":[{"value":"2026-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e73312"}}