{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:58:18Z","timestamp":1792155498137,"version":"4.4.0"},"reference-count":61,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The increased likelihood of potential drug\u2013drug interactions (PDDIs) and food\u2013drug interactions (FDIs) is primarily attributed to the increasing use of multiple medications and the practice of taking medicines with food. Healthcare professionals' (HCPs') knowledge and attitudes toward PDDIs and FDIs play a critical role in ensuring patient safety and effective medication management. An increase in PDDIs and FDIs can compromise patient safety, decrease treatment efficacy, and increase healthcare costs. Therefore, this study aimed to assess the knowledge and attitudes toward PDDIs and FDIs, as well as associated factors, among HCPs at the University of Gondar Comprehensive Specialised Hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital. Healthcare professionals' knowledge of PDDIs and FDIs was assessed using a self\u2010administered questionnaire. To examine knowledge predictors, we conducted a regression analysis. Data analysis was done using SPSS version 27.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were 328 HCPs involved in this study; 325 completed the study, with a 99.1% response rate;\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20093 were excluded due to declining participation or unavailability during data collection. For acetaminophen, codeine, and amoxicillin, the HCPs' PDDIs knowledge levels were 219 (67.4%), whereas 66 (20.3%) were for carbamazepine and cimetidine. Regarding the FDI\u2010related questions, HCPs answered items most frequently correctly on patients taking sulfa drugs with folate\u2010containing foods (251; 77.2%), followed by patients taking antibiotics who should avoid acidic foods such as citrus juice (245; 75.4%). Multivariable analysis revealed that being trained as a pharmacists: AOR: 13.222, 95% CI: 6.785\u201330.769; medical doctors: AOR 11.265, 95% CI: 8.205\u201314.960; and age &gt;\u200940 years: AOR 12.673, 95% CI: 1.875\u201385.646 were significantly associated with HCPs' knowledge of PDDIs and FDIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on the results of this study, a minority of HCPs demonstrated good knowledge of potential drug\u2013drug interactions (30.5%) and food\u2013drug interactions (32.0%), indicating notable gaps in knowledge.<\/jats:p>\n                  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