{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:54:53Z","timestamp":1792050893189,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Human astrovirus (HAstV) is a recognized cause of viral gastroenteritis, however, data from north\u2010central Nigeria remain limited. This study aimed to determine the prevalence of classic HAstV RNA and explore associated factors among children under 5 years presenting with gastroenteritis in Ilorin, Nigeria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This hospital\u2010based cross\u2010sectional study was conducted from May 2025 to September 2025 among 200 children aged 13\u201359 months attending selected hospitals in Ilorin who presented consecutively. Stool samples were collected and analyzed using real\u2010time reverse transcription polymerase chain reaction for classic HAstV RNA. Data were analyzed using R software. Participant characteristics were summarized descriptively, prevalence estimates were calculated with exact 95% confidence intervals, and associations with astrovirus detection were evaluated using Fisher's exact test, the Wilcoxon rank\u2010sum test, and Firth penalized logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Classic HAstV RNA was detected in 4 of 200 children under 5 years with acute gastroenteritis, giving an overall prevalence of 2.0% (4\/200; 95% CI: 0.55%\u20135.04%). Prevalence was highest among children aged 49\u201360 months (2.94%), males (2.50%), rural residents (2.33%), users of borehole\/well water (2.86%), and children attending daycare (4.0%). All astrovirus\u2010positive children presented with vomiting, moderate dehydration, resided in rural communities, had animal contact, used borehole\/well water, and received oral rehydration solution. No other characteristics were significantly associated with HAstV. Feeding method was the only factor significantly associated with detection (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), with the highest prevalence among exclusively breastfed children (33.3%; 2\/6). However, wide confidence intervals around both the raw prevalence and the adjusted odds ratio (aOR\u2009=\u20090.01; 95% CI: 0.00\u20130.29) indicate this finding is exploratory rather than confirmed, warranting confirmation in larger studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Astrovirus in this population is relatively low; however, it remains epidemiologically important, particularly as prevalence may vary with season. Continued surveillance and further molecular characterization are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73388","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:53:46Z","timestamp":1791878026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Molecular Prevalence of Human Astrovirus Among Children Under Five Years of Age With Gastroenteritis in Ilorin Metropolis, North\u2010Central Nigeria: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8431-3033","authenticated-orcid":false,"given":"Pius Omoruyi","family":"Omosigho","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Science Edo State University Uzairue Benin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1612-7199","authenticated-orcid":false,"given":"Toluwalope Serah","family":"Famuwagun","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science University of Ilorin Ilorin Kwara State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9835-9554","authenticated-orcid":false,"given":"Eunice Korede","family":"Ogunleye","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and parasitology University of Ilorin Teaching Hospital Ilorin Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3546-087X","authenticated-orcid":false,"given":"Adeleke","family":"Adewumi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Unit, University Health Centre Ladoke Akintola University of Technology Ogbomoso Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3809-4271","authenticated-orcid":false,"given":"Olalekan John","family":"Okesanya","sequence":"additional","affiliation":[{"name":"Department of Research, Global Health Focus University of Rwanda Kigali Rwanda"},{"name":"Department of Public Health, Faculty of Medicine and Health Sciences Hormuud University Mogadishu Somalia"},{"name":"Department of Medical Laboratory Science, Neuropsychiatric Hospital Aro Neuropsychiatric Hospital Aro Abeokuta 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