{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:49:55Z","timestamp":1792388995385,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009329","name":"Scientific Research and Technology Development Program of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["GK AB25069055"],"award-info":[{"award-number":["GK AB25069055"]}],"id":[{"id":"10.13039\/501100009329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Breast cancer is the most common invasive malignancy in women. Ultrasound viscoelastography may improve non\u2010invasive diagnosis, but the clinical relevance of peritumoral viscoelastic parameters (VPs) and their correlation with Ki\u201067 remain unclear. This study explores these associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective study enrolled 256 breast masses (156 malignant, 100 benign). Patients underwent conventional ultrasound and viscoelastography. VPs were acquired within masses (A), peritumoral shells (Shell1: 1\u2009mm, Shell2: 2\u2009mm, Shell3: 3\u2009mm), and combined regions (A'\u2009=\u2009A + Shell). Quantitative metrics included elasticity (V\/1 E, V\/0 E), dispersion coefficient (V\/1 D), viscosity coefficient (V\/0\u2009V), and their maximum (Max), minimum (Min), mean(Mean), and standard deviation (SD) values. Diagnostic performance was evaluated by analyzing the receiver operating characteristic (ROC) curve and calculating the area under the curve (AUC), followed by logistic regression. VPs were compared between high\/low Ki\u201067 groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The AUCs of peritumoral VPs exceeded those from masses. V\/1 D showed higher AUC than V\/0\u2009V and elasticity values, with Shell3 V\/1 D SD having the highest AUC (0.840). The diagnostic efficacy of the peritumoral viscoelastic model surpassed that of the single elasticity parameter model, with 89.1% sensitivity, 73% specificity, 82.8% accuracy. Key variables included Shell3 V\/1 D and Shell3 V\/0 E. Shell1 V\/0\u2009V Max was significantly higher in high versus low Ki\u201067 expression groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The viscoelastic model improves diagnostic accuracy by quantifying peritumoral biomechanics, and certain VPs may predict Ki\u201067 expression. Peritumoral VPs show potential as novel non\u2010invasive imaging biomarkers for early breast cancer evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.73394","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T05:37:53Z","timestamp":1792388273000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Advancing Early Breast Cancer Diagnosis and Ki\u201067 Expression Prediction With Ultrasound Viscoelastography: Based on Peritumoral Assessment"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-8508","authenticated-orcid":false,"given":"Xiaoli","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Ultrasound The First Affiliated Hospital of Jinan University Guangzhou China"},{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7089-7293","authenticated-orcid":false,"given":"Chunxiang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7565-2607","authenticated-orcid":false,"given":"Demao","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6195-2924","authenticated-orcid":false,"given":"Quanqing","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"9","key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.4067\/S0034-98872020000901239","article-title":"Diagnostic Values of Shear Wave Elastography and Strain Elastography for Breast Lesions","volume":"148","author":"Jiang H.","year":"2020","journal-title":"Revista M\u00e9dica de Chile"},{"issue":"5","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.ultrasmedbio.2015.03.008","article-title":"WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 2: Breast","volume":"41","author":"Barr R. 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