{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T01:58:05Z","timestamp":1773453485936,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>The severe acute respiratory syndrome coronavirus 2\u00a0(SARS\u2010CoV\u20102) is known to affect multiple organs by binding to angiotensin\u2010converting enzyme 2 receptors and might therefore affect male fertility. This review aims to collect all original articles on the effects of SARS\u2010CoV\u20102 infection on male fertility, including the duration of time after infection required for these effects to begin to manifest and recommend how clinicians should approach cases with a recent illness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review was developed according to the preferred reporting items for systematic reviews and meta\u2010analyses guidelines. The search string was applied to four online databases\u2014namely Pubmed, Embase, Medline, and the Cochrane COVID\u201019\u00a0Register\u2014and screened using the online tool <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/Covidence.org\">Covidence.org<\/jats:ext-link>. Articles were eligible for inclusion if they were cohort studies involving a healthy male population diagnosed with COVID\u201019, each of whom had semen samples collected before and after the infection or two different semen samples collected after the diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine cohort studies were eventually included. Five articles had pre\u2010 and post\u2010COVID\u201019 data while four had two sets of post\u2010COVID\u201019 data. The three largest studies found a statistically significant decrease in all semen parameters when waiting less than 3 months from diagnosis before sample collection, and no significant differences in results when the ejaculate was analyzed more than 3 months after recovery. One study compared the COVID\u201019 patients with a control group and found a significant decrease in semen parameters in the COVID\u201019 group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Spermatogenesis seems to be affected by SARS\u2010CoV\u20102 infection, but the impact tends to reverse within 3\u20134 months. It is still unclear why male fertility is affected by SARS\u2010CoV\u20102 infection, and it might be the result of several different components. Clinicians should consider recent SARS\u2010CoV\u20102 infection as a possible reason for the low semen quality of patients' semen samples, and might therefore need to collect new samples after 4 months before further treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.745","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:13:21Z","timestamp":1660119201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Semen parameters after SARS\u2010CoV\u20102 infection: A literature review"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-5455","authenticated-orcid":false,"given":"Kathrine","family":"Tufvesson","sequence":"first","affiliation":[{"name":"Research Unit of Reproductive Medicine, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Centre of Andrology and Fertility Clinic Dept. D, Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-4281","authenticated-orcid":false,"given":"Laura","family":"Catalini","sequence":"additional","affiliation":[{"name":"Research Unit of Reproductive Medicine, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Centre of Andrology and Fertility Clinic Dept. D, Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5383-5501","authenticated-orcid":false,"given":"Jens","family":"Fedder","sequence":"additional","affiliation":[{"name":"Research Unit of Reproductive Medicine, Faculty of Health Sciences University of Southern Denmark  Odense Denmark"},{"name":"Centre of Andrology and Fertility Clinic Dept. 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