{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:55:50Z","timestamp":1763664950476,"version":"3.41.2"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Bismuth quadruple (BQ) therapy is known to have poor patient compliance and a complex dosing method, and no appropriate third\u2010line regimen exists if second\u2010line BQ therapy fails. In Korea, some alternative regimens have shown unsatisfactory eradication rates. Therefore, we investigated the success rates of the second\u2010line moxifloxacin\u2013rifabutin triple (MRT) regimen and compared it with BQ regimen in subgroup analysis of peptic ulcer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This study was a retrospective study of 71 patients who underwent a second\u2010line MRT for <jats:italic>Helicobacter pylori<\/jats:italic> after failing to clarithromycin triple regimen. To compare the eradication rate in gastric ulcer patients, 51 patients in the MRT group and 132 patients in BQ group were included. After age and sex propensity matching, 45 patients were included in each group (the alpha value and power were set at 0.05% and 77%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The eradication rate in the MRT group was 69.0% (49\/71) in the intention\u2010to\u2010treat (ITT) analysis and 77.8% (49\/63) in the per\u2010protocol (PP) analysis. These were significantly lower than the eradication rate in the BQ group (82.5%, <jats:italic>p<\/jats:italic>\u2009=\u20090.019 in the ITT analysis; 89.3%, <jats:italic>p<\/jats:italic>\u2009=\u20090.022 in the PP analysis). In subgroup analysis of peptic ulcer patients, the success rate of BQ group was significantly higher than that of MRT group in both ITT and PP populations (81.8% (108\/132) vs. 60.8% (31\/51) in the ITT populations, <jats:italic>p<\/jats:italic>\u2009=\u20090.004; and 90.0% (108\/120) vs. 72.1% (31\/43) in the PP populations, <jats:italic>p<\/jats:italic>\u2009=\u20090.010). Among the 14 patients with MRT therapy failure, 10 were eradicated with BQ as the third\u2010line regimen. The eradication rate of the third\u2010line BQ after the second\u2010line MRT failure was 90.0% (9\/10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Second\u2010line MRT therapy was not as effective as BQ therapy, so it should be considered for limited use only when BQ is not available.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.780","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T04:48:53Z","timestamp":1661316533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of eradication rates of moxifloxacin\u2013rifabutin triple therapy and bismuth quadruple therapy as second\u2010line regimens in patients with peptic ulcers"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5587-2023","authenticated-orcid":false,"given":"Chang Min","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Gyeongsang National University Institute of Health Sciences  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong Je","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se In","family":"Hah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yoon","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Woo","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Chin","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Gyeongsang National University Institute of Health Sciences  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Yoon","family":"Ha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Gyeongsang National University Institute of Health Sciences  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ok Jae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Gyeongsang National University Institute of Health Sciences  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woon Tae","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Gyeongsang National University College of Medicine and Gyeongsang National University Hospital  Jinju Republic of Korea"},{"name":"Gyeongsang National University Institute of Health Sciences  Jinju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-014-3093-7"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2009.00738.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/47.4.459"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.12.4843-4847.2004"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2011.57.4.221"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i22.6932"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2019.73.1.26"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12561"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12660"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.2007.00588.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2017.69.2.109"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12147"}],"container-title":["Health 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