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Two immune response deteriorating factors are considered to be responsible for immunosuppression: comorbidities and medication. Due to unlike infection sites and patterns, CAM and CAA\u2010associated\u00a0factors deflect a few degrees of proximity, and the present study is for its assessment. The study evaluated 351 CAM cases and 191 CAA cases retrieved from 65 and 53 articles based on inclusion criteria, respectively. Most of the CAM reported from India and CAA were from four South\u2010European and West\u2010European neighbor countries. The mean ages of CAM and CAA were 52.72\u2009\u00b1\u200913.74 and 64.81\u2009\u00b1\u200911.14, correspondingly. Mortality of CAA (56.28%) was two times greater than CAM (26.02%). Nevertheless, the count of diabetes cases was very high in CAM compared to CAA. The main comorbidities of CAM were diabetes (nearly 80%) and hypertension (more than 38%). All noticeable complications were higher in CAA except diabetes, and these were diabetes (34.55%), hypertension (45.03%), and obesity (18.32%). Moreover, pre\u2010existing respiratory complications like asthma and chronic obstructive pulmonary disease are\u00a0visible in CAA. The uses of steroids in CAM and CAA were nearly 70% and 66%, respectively. Almost one\u2010fourth of CAA cases were reported using immunosuppressant monoclonal antibodies, whereas only 7.69% were for CAM. 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