{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:35:41Z","timestamp":1790854541662,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007941","name":"Addis Ababa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Pregnancy\u2010induced hypertension is one of the top three ranked diseases during pregnancy that cause maternal, fetal, and neonatal morbidity and mortality worldwide. To provide adequate information to clinicians and researchers who are striving for potential interventions, biochemical profiling of such patients is required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A hospital\u2010based case\u2010control study design was conducted from August 2020 to May 2021 to evaluate serum lipid profile, uric acid, and high sensitivity C\u2010reactive protein (hs\u2010CRP) among women with pregnancy\u2010induced hypertension compared to normotensive pregnant women. Data were entered and analyzed using SPSS version 25. Independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test and\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      were used to compare the relationship of variables between the\u00a0two groups. A\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value less than 0.05 was used to test statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The result of this study showed that while the levels (mean\u2009\u00b1\u2009SD) of serum total cholesterol (TC), triglyceride\u00a0(TG), low\u2010density lipoprotein\u2010cholesterol\u00a0(LDL\u2010C), TC\/high\u2010density lipoprotein\u2010cholesterol (HDL\u2010C), TG\/HDL\u2010C, LDL\u2010C\/HDL\u2010C were significantly elevated, HDL\u2010C was decreased among women with pregnancy\u2010induced hypertension than normotensive pregnant women (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001). The levels (mean\u2009\u00b1\u2009SD) of uric acid and hs\u2010CRP were significantly higher among women with pregnancy\u2010induced hypertension compared to normotensive pregnant women (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study indicated that pregnancy\u2010induced hypertension women have lipid abnormalities, increased systemic inflammatory markers, and hyperuricemia compared to normotensive pregnant women. Thus, women with PIH showing high dyslipidemia, hyperuricemia, and inflammation are likely to develop hypertension. Therefore, evaluation of these potential biomarkers during early antenatal care services may help seek interventions in PIH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.806","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T14:38:07Z","timestamp":1662043087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of serum lipid profiles, uric acid, and high sensitivity C\u2010reactive protein levels between pregnancy\u2010induced hypertension and normotensive pregnant women attending Ambo University Referral Hospital, Ambo, Ethiopia, 2020: A case\u2010control study"],"prefix":"10.1002","volume":"5","author":[{"given":"Bilisuma G.","family":"Areda","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health Sciences Haramaya University Haramaya Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5281-8611","authenticated-orcid":false,"given":"Solomon T.","family":"Gizaw","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health Sciences Addis Ababa University Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delesa H.","family":"Berdida","sequence":"additional","affiliation":[{"name":"Ambo University Referral Hospital Ambo Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbul H.","family":"Kebalo","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, School of Medicine, College of Health Sciences Madda Walabu University Robe Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9]]},"reference":[{"issue":"04","key":"e_1_2_15_2_1","first-page":"703","article-title":"Study of risk factors of perinatal death in pregnancy induced hypertension (PIH)","volume":"3","author":"Parmar MT","year":"2012","journal-title":"Natl J\u00a0Community Med"},{"key":"e_1_2_15_3_1","volume-title":"Hypertensive Disorders in Pregnancy guideline summary","author":"Kacica M","year":"2013"},{"issue":"5","key":"e_1_2_15_4_1","first-page":"1122","article-title":"Task force on hypertension in pregnancy. 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