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Generally, prisoners are at higher risks for STIs due to risk factors including; drug\u2010use, high\u2010risk sexual behaviors, densely populated prisons, and poor living conditions. Therefore, we aimed to conduct a systematic review to evaluate the existing data on STI prevalence, and its associated risk factors among prisoners.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic search of the literature using the keywords in Scopus, PubMed, Web of Science, and Google Scholar online databases. We selected all the relevant original studies in English through title\/abstract and full\u2010text screening process.\u200e<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Based on the inclusion and exclusion criteria, we selected and reviewed 32 studies out of 96 identified papers. The most important STI\u2010associated risk factors among prisoners were drug use, low educational levels, and unsafe sex. The prevalence of STIs was heterogenous in selected studies and was reported as follows; Human Immunodeficiency Virus (HIV)\u00a0(0%\u221214.5%), hepatitis B viruses (HBV) (0.04%\u221227.23%), hepatitis C viruses (HCV) (0.17%\u221249.7%), Syphilis (0.2%\u221222.1%), Chlamydia Trachomatis (CT) (1.02%\u22126.7%), Gonorrhea (0.6%\u22127.8%), and herpes simplex virus\u20102 (HSV\u20102) 22.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systematic review indicates that the prevalence of STIs (HIV, HBV, HCV, Syphilis, Chlamydia Trachomatis, Gonorrhea, and HSV\u20102) among prisoners appears to be higher than the general population, with drug abuse, low educational levels, and unsafe sex as major risk 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