{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T19:59:53Z","timestamp":1766087993265,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>An autonomic nervous disorder is an important characteristic of cardiac amyloidosis; however, the prevalence of autonomic dysfunction in wild\u2010type transthyretin amyloidosis (ATTR<jats:sub>wt<\/jats:sub>) has not been established. Analysis of the R\u2010R interval coefficient of variation (CVR\u2010R) is a noninvasive method to measure parasympathetic activity. We aimed to assess autonomic dysfunction of ATTR<jats:sub>wt<\/jats:sub> and determine the utility of CVR\u2010R for the detection of ATTR<jats:sub>wt<\/jats:sub> in other cardiac diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center, retrospective, case\u2010control study. Fifty patients with heart failure (HF) were studied. The etiologies of HF were as follows: ATTR<jats:sub>wt<\/jats:sub>, <jats:italic>n<\/jats:italic>\u2009=\u200910; previous myocardial infarction (MI), <jats:italic>n<\/jats:italic>\u2009=\u200920; and left ventricular hypertrophy (LVH) due to other disease processes (e.g., aortic stenosis), <jats:italic>n<\/jats:italic>\u2009=\u200920. We measured the CVR\u2010R at rest (CVR\u2010R<jats:sub>rest<\/jats:sub>), CVR\u2010R with deep breaths (CVR\u2010R<jats:sub>breath<\/jats:sub>), and the change rate (CVR\u2010R<jats:sub>diff rate)<\/jats:sub>. The relative change formula is as follows: CVR\u2010R<jats:sub>diff rate<\/jats:sub>\u2009=\u2009(CVR\u2010R<jats:sub>breath<\/jats:sub>\u2009\u2212\u2009CVR\u2010R<jats:sub>rest<\/jats:sub>)\/CVR\u2010R<jats:sub>rest<\/jats:sub>\u2009100 (%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no difference in the CVR\u2010R<jats:sub>rest<\/jats:sub> levels among the three groups. The CVR\u2010R<jats:sub>diff rate<\/jats:sub> levels in the ATTR<jats:sub>wt<\/jats:sub> group were significantly lower (ATTR<jats:sub>wt<\/jats:sub>: \u22128.77 [\u221243.8 to 10.9]; LVH: 67.4 [38.7 to 89.4]; MI: 83.7 [60.4 to 142.9]). Based on the receiver operative characteristic curve analysis to identify ATTR<jats:sub>wt<\/jats:sub> in HF, the best cut\u2010off value for the CVR\u2010R<jats:sub>diff rate<\/jats:sub> was 19.7 (area under the curve: 0.848).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our data suggested autonomic dysfunction in patients with ATTR<jats:sub>wt<\/jats:sub>. Measurement of the CVR\u2010R in HF patients may be a convenient support tool for the detection of ATTR<jats:sub>wt<\/jats:sub>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.938","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T14:21:58Z","timestamp":1669818118000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Coefficient of R\u2010R interval variations under deep breathing load in patients with wild\u2010type transthyretin amyloid cardiomyopathy: A case\u2010control study"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1696-0466","authenticated-orcid":false,"given":"Yasuhiro","family":"Nagayoshi","sequence":"first","affiliation":[{"name":"Department of Cardiology Amakusa Medical Center  Amakusa Japan"},{"name":"Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University  Kumamoto 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