{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:13:22Z","timestamp":1790964802603,"version":"4.1.0"},"reference-count":13,"publisher":"Hindawi Limited","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4948,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"name":"DGICYT, Ministerio de Educaci\u00f3n y Ciencia, Spain","award":["PB97-0034"],"award-info":[{"award-number":["PB97-0034"]}]},{"DOI":"10.13039\/100012818","name":"Comunidad de Madrid","doi-asserted-by":"crossref","award":["003\/97"],"award-info":[{"award-number":["003\/97"]}],"id":[{"id":"10.13039\/100012818","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mutat."],"published-print":{"date-parts":[[2002,3]]},"DOI":"10.1002\/humu.10050","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T04:51:41Z","timestamp":1030251101000},"page":"234-239","source":"Crossref","is-referenced-by-count":16,"title":["The A8296G mtDNA mutation associated with several mitochondrial diseases does not cause mitochondrial dysfunction in cybrid cell lines"],"prefix":"10.1155","volume":"19","author":[{"given":"Bel\u00e9n","family":"Bornstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Antonio","family":"Mas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Fern\u00e1ndez-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Angel","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"del Hoyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Garesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2002,2,13]]},"reference":[{"key":"10.1002\/humu.10050-BIB01|cit1","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1098-1004(200004)15:4<382::AID-HUMU15>3.0.CO;2-B","article-title":"Fatal hypertrophyc cardiomyopathy associated with an A8296G mutation in the mitochondrial tRNA (Lys) gene","volume":"15","author":"Akita","year":"2000","journal-title":"Hum Mutat"},{"key":"10.1002\/humu.10050-BIB02|cit2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/S0002-9440(10)65738-0","article-title":"Mitochondrial DNA mutations and mitochondrial abnormalities in dilated cardiomyopathy","volume":"153","author":"Arbustini","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1002\/humu.10050-BIB03|cit3","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1212\/WNL.52.2.377","article-title":"A double mutation (A8296G and G8363A) in the mitochondrial DNA tRNA (Lys) gene associated with myoclonus epilepsy with ragged-red fibers","volume":"52","author":"Arenas","year":"1999","journal-title":"Neurology"},{"key":"10.1002\/humu.10050-BIB04|cit4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0076-6879(96)64020-8","article-title":"In vivo labeling and analysis of human mitochondrial translation products","volume":"264","author":"Chomyn","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1002\/humu.10050-BIB05|cit5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1750-3639.2000.tb00275.x","article-title":"Mutations in mtDNA: are we scraping the bottom of the barrel?","volume":"71","author":"DiMauro","year":"2000","journal-title":"Brain Pathol"},{"key":"10.1002\/humu.10050-BIB06|cit6","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.2337\/diacare.21.11.2034","article-title":"Impaired insuline secretion in Japanese diabetic subjects with an A-to-G mutation at nucleotide 8296 of the mitochondrial DNA in tRNA (Lys)","volume":"21","author":"Kamekoa","year":"1998a","journal-title":"Diabetes Care"},{"key":"10.1002\/humu.10050-BIB07|cit7","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1006\/bbrc.1998.8437","article-title":"Novel mitochondrial DNA mutation in tRNA (Lys) (8296 A->G) associated with diabetes","volume":"245","author":"Kamekoa","year":"1998b","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/humu.10050-BIB08|cit8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1002\/humu.10050-BIB09|cit9","first-page":"79","volume-title":"Mitochondria: a practical approach","author":"Ragan","year":"1987"},{"key":"10.1002\/humu.10050-BIB10|cit10","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/35072063","article-title":"The genetics and pathology of oxidative phosphorylation","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nat Rev Genet"},{"key":"10.1002\/humu.10050-BIB11|cit11","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/brain\/124.5.984","article-title":"Mitochondrial DNA transfer RNA gene sequence variations in patients with mitochondrial disorders","volume":"124","author":"Sternberg","year":"2001","journal-title":"Brain"},{"key":"10.1002\/humu.10050-BIB12|cit12","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/hmg\/4.11.2017","article-title":"Nuclear DNA origin of cytochrome c oxidase deficiency in Leigh\u2019s syndrome: genetic evidence based on patient\u2019s derived \u03c10 degrees transformants","volume":"4","author":"Tiranti","year":"1995","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.10050-BIB13|cit13","doi-asserted-by":"crossref","first-page":"11164","DOI":"10.1073\/pnas.89.23.11164","article-title":"Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy","volume":"89","author":"Yoneda","year":"1992","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.10050","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/humu.10050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T21:25:50Z","timestamp":1703885150000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.10050"}},"subtitle":["Re-Evaluation of MtDNA A8296G Pathogenicity"],"short-title":[],"issued":{"date-parts":[[2002,2,13]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3]]}},"URL":"https:\/\/doi.org\/10.1002\/humu.10050","archive":["Portico"],"relation":{},"ISSN":["1059-7794"],"issn-type":[{"value":"1059-7794","type":"print"}],"subject":[],"published":{"date-parts":[[2002,2,13]]}}}