{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:40:19Z","timestamp":1790628019212,"version":"4.1.0"},"reference-count":24,"publisher":"Hindawi Limited","issue":"6","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":4306,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mutat."],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1002\/humu.10272","type":"journal-article","created":{"date-parts":[[2003,11,18]],"date-time":"2003-11-18T21:23:16Z","timestamp":1069190596000},"page":"423-427","source":"Crossref","is-referenced-by-count":50,"title":["SomaticNF1 mutation spectra in a family with neurofibromatosis type 1: Toward a theory of genetic modifiers"],"prefix":"10.1155","volume":"22","author":[{"given":"Verena","family":"Wiest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Eisenbarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Schmegner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Winfrid","family":"Krone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\ufffdnter","family":"Assum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2003,11,17]]},"reference":[{"key":"BIB1","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/356713a0","volume":"356","author":"Basu","year":"1992","journal-title":"Nature"},{"key":"BIB2","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/ng0995-90","volume":"11","author":"Colman","year":"1995","journal-title":"Nat Genet"},{"key":"BIB3","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/bbrc.1997.6645","volume":"234","author":"Daeschner","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"BIB4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0092-8674(92)90407-4","volume":"69","author":"DeClue","year":"1992","journal-title":"Cell"},{"key":"BIB5","first-page":"305","volume":"53","author":"Easton","year":"1993","journal-title":"Am J Hum Genet"},{"key":"BIB6","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1086\/302747","volume":"66","author":"Eisenbarth","year":"2000","journal-title":"Am J Hum Genet"},{"key":"BIB7","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1086\/302809","volume":"66","author":"Fahsold","year":"2000","journal-title":"Am J Hum Genet"},{"key":"BIB8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/hmg\/4.6.975","volume":"4","author":"Heim","year":"1995","journal-title":"Hum Mol Genet"},{"key":"BIB9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s004390000322","volume":"107","author":"Horan","year":"2000","journal-title":"Hum Genet"},{"key":"BIB10","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1136\/jmg.37.1.44","volume":"37","author":"John","year":"2000","journal-title":"J Med Genet"},{"key":"BIB11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0165-4608(99)00006-0","volume":"113","author":"Kluwe","year":"1999","journal-title":"Cancer Genet Cytogenet"},{"key":"BIB12","first-page":"725","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Adad Sci USA"},{"key":"BIB13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0302-2838(02)00280-4","volume":"42","author":"Maier","year":"2002","journal-title":"Eur Urol"},{"key":"BIB14","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1038\/sj.onc.1202764","volume":"18","author":"Mancini","year":"1999","journal-title":"Oncogene"},{"key":"BIB15","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/1098-1004(200006)15:6<541::AID-HUMU6>3.0.CO;2-N","volume":"15","author":"Messiaen","year":"2000","journal-title":"Hum Mutat"},{"key":"BIB16","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/1098-2264(200008)28:4<425::AID-GCC8>3.0.CO;2-E","volume":"28","author":"Rasmussen","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"BIB17","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/ng0996-110","volume":"14","author":"Sawada","year":"1996","journal-title":"Nat Genet"},{"key":"BIB18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/515504","volume":"61","author":"Serra","year":"1997","journal-title":"Am J Hum Genet"},{"key":"BIB19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s004390100514","volume":"108","author":"Serra","year":"2001a","journal-title":"Hum Genet"},{"key":"BIB20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/90148","volume":"28","author":"Serra","year":"2001b","journal-title":"Nat Genet"},{"key":"BIB21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/archneur.1988.00520290115023","volume":"45","author":"Stumpf","year":"1988","journal-title":"Arch Neurol"},{"key":"BIB22","first-page":"65","volume-title":"Neurofibromatosis type 1 from genotype to phenotype","author":"Upadhyaya","year":"1998","unstructured":"1998. Neurofibromatosis type 1 from genotype to phenotype. Oxford: BIOS Scientific. p 65-82."},{"key":"BIB23","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s004390050746","volume":"102","author":"Upadhyaya","year":"1998","journal-title":"Hum Genet"},{"key":"BIB24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00439-002-0858-4","volume":"112","author":"Wang","year":"2003","journal-title":"Hum Genet"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.10272","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/humu.10272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:50:52Z","timestamp":1672332652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.10272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,17]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"URL":"https:\/\/doi.org\/10.1002\/humu.10272","relation":{},"ISSN":["1059-7794","1098-1004"],"issn-type":[{"value":"1059-7794","type":"print"},{"value":"1098-1004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,17]]}}}