{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:57:06Z","timestamp":1793987826686,"version":"4.8.0"},"reference-count":121,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2800,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mutat."],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1002\/humu.20605","type":"journal-article","created":{"date-parts":[[2007,9,19]],"date-time":"2007-09-19T06:18:41Z","timestamp":1190182721000},"page":"22-32","source":"Crossref","is-referenced-by-count":570,"title":["Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene"],"prefix":"10.1155","volume":"29","author":[{"given":"Manuel C.","family":"Lemos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh V.","family":"Thakker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"10.1002\/humu.20605-BIB1","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/hmg\/6.7.1169","article-title":"Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states","volume":"6","author":"Agarwal","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.20605-BIB2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0092-8674(00)80967-8","article-title":"Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription","volume":"96","author":"Agarwal","year":"1999","journal-title":"Cell"},{"key":"10.1002\/humu.20605-BIB3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1055\/s-2005-870139","article-title":"Menin molecular interactions: insights into normal functions and tumorigenesis","volume":"37","author":"Agarwal","year":"2005","journal-title":"Horm Metab Res"},{"key":"10.1002\/humu.20605-BIB4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tem.2006.09.004","article-title":"Menin and its interacting proteins: elucidation of menin function","volume":"17","author":"Balogh","year":"2006","journal-title":"Trends Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB5","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/jmg.2004.029538","article-title":"Splicing in action: assessing disease causing sequence changes","volume":"42","author":"Baralle","year":"2005","journal-title":"J Med Genet"},{"key":"10.1002\/humu.20605-BIB6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1","volume":"62","author":"Bassett","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.20605-BIB7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1359\/jbmr.1999.14.1.3","article-title":"Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, Men1","volume":"14","author":"Bassett","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1002\/humu.20605-BIB8","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/0002-9343(87)90008-8","article-title":"Hyperparathyroidism presenting as the first lesion in multiple endocrine neoplasia type 1","volume":"82","author":"Benson","year":"1987","journal-title":"Am J Med"},{"key":"10.1002\/humu.20605-BIB9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1054\/bjoc.2000.1380","article-title":"Identification of MEN1 gene mutations in families with MEN 1 and related disorders","volume":"83","author":"Bergman","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1002\/humu.20605-BIB10","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/me.2003-0154","article-title":"Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1","volume":"17","author":"Bertolino","year":"2003","journal-title":"Mol Endocrinol"},{"key":"10.1002\/humu.20605-BIB11","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0925-4773(03)00039-X","article-title":"Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs","volume":"120","author":"Bertolino","year":"2003","journal-title":"Mech Dev"},{"key":"10.1002\/humu.20605-BIB12","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.1523-1747.1998.00317.x","article-title":"Somatic mutations of the MEN1 tumor suppressor gene detected in sporadic angiofibromas","volume":"111","author":"Boni","year":"1998","journal-title":"J Invest Dermatol"},{"key":"10.1002\/humu.20605-BIB13","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB14","first-page":"2642","article-title":"Spectrum of pituitary disease in multiple endocrine neoplasia type 1 (MEN 1): clinical, biochemical, and radiological features of pituitary disease in a large MEN 1 kindred","volume":"81","author":"Burgess","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB15","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1046\/j.1365-2796.1998.00275.x","article-title":"Expression of the MEN-1 gene in a large kindred with multiple endocrine neoplasia type 1","volume":"243","author":"Burgess","year":"1998","journal-title":"J Intern Med"},{"key":"10.1002\/humu.20605-BIB16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1046\/j.1365-2265.2000.01032.x","article-title":"Phenotype and phenocopy: the relationship between genotype and clinical phenotype in a single large family with multiple endocrine neoplasia type 1 (MEN 1)","volume":"53","author":"Burgess","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1002\/humu.20605-BIB17","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1158\/0008-5472.CAN-06-0061","article-title":"Multiple endocrine neoplasia type 1 interacts with forkhead transcription factor CHES1 in DNA damage response","volume":"66","author":"Busygina","year":"2006","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB18","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1073\/pnas.87.5.1968","article-title":"Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors","volume":"87","author":"Bystrom","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2796.1995.tb00933.x","article-title":"Multiple endocrine neoplasia type 1 in France: clinical and genetic studies","volume":"238","author":"Calender","year":"1995","journal-title":"J Intern Med"},{"key":"10.1002\/humu.20605-BIB20","first-page":"2960","article-title":"Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism","volume":"83","author":"Carling","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB21","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1136\/jmg.40.5.e72","article-title":"Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients","volume":"40","author":"Cebrian","year":"2003","journal-title":"J Med Genet"},{"key":"10.1002\/humu.20605-BIB22","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia-type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"10.1002\/humu.20605-BIB23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1365-2796.2003.01165.x","article-title":"Functional studies of the MEN1 gene","volume":"253","author":"Chandrasekharappa","year":"2003","journal-title":"J Intern Med"},{"key":"10.1002\/humu.20605-BIB24","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.98.3.1118","article-title":"A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors","volume":"98","author":"Crabtree","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB25","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1046\/j.1365-2362.2000.00620.x","article-title":"Lack of MEN1 gene mutations in 27 sporadic insulinomas","volume":"30","author":"Cupisti","year":"2000","journal-title":"Eur J Clin Invest"},{"key":"10.1002\/humu.20605-BIB26","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1093\/hmg\/6.13.2285","article-title":"Identification of MEN1 gene mutations in sporadic carcinoid tumors of the lung","volume":"6","author":"Debelenko","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.20605-BIB27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004390100505","article-title":"Nomenclature for the description of human sequence variations","volume":"109","author":"den Dunnen","year":"2001","journal-title":"Hum Genet"},{"key":"10.1002\/humu.20605-BIB28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s002689900438","article-title":"Lethality of multiple endocrine neoplasia type I","volume":"22","author":"Doherty","year":"1998","journal-title":"World J Surg"},{"key":"10.1002\/humu.20605-BIB29","doi-asserted-by":"crossref","first-page":"4929","DOI":"10.1158\/0008-5472.CAN-05-4461","article-title":"Menin links estrogen receptor activation to histone H3K4 trimethylation","volume":"66","author":"Dreijerink","year":"2006","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB30","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/6.7.1177","article-title":"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1","volume":"6","year":"1997","unstructured":"European Consortium on MEN1. 1997. Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1. Hum Mol Genet 6:1177-1183.","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.20605-BIB31","first-page":"2627","article-title":"Alterations of the MEN1 gene in sporadic parathyroid tumors","volume":"83","author":"Farnebo","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB32","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJM198907273210402","article-title":"Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1","volume":"321","author":"Friedman","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1002\/humu.20605-BIB33","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1046\/j.1440-1827.1999.00971.x","article-title":"MEN1 gene mutations in sporadic neuroendocrine tumors of foregut derivation","volume":"49","author":"Fujii","year":"1999","journal-title":"Pathol Int"},{"key":"10.1002\/humu.20605-BIB34","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1038\/sj.onc.1205822","article-title":"Menin uncouples Elk-1, JunD and c-Jun phosphorylation from MAP kinase activation","volume":"21","author":"Gallo","year":"2002","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB35","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1086\/301953","article-title":"Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders","volume":"63","author":"Giraud","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.20605-BIB36","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<373::AID-IJC7>3.0.CO;2-B","article-title":"MEN1 gene mutation analysis of sporadic adrenocortical lesions","volume":"80","author":"Gortz","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1002\/humu.20605-BIB37","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9440(10)65289-3","article-title":"Mutations and allelic deletions of the MEN1 gene are associated with a subset of sporadic endocrine pancreatic and neuroendocrine tumors and not restricted to foregut neoplasms","volume":"154","author":"Gortz","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1002\/humu.20605-BIB38","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1073\/pnas.95.4.1630","article-title":"Menin, the product of the MEN1 gene, is a nuclear protein","volume":"95","author":"Guru","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB39","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s100380050105","article-title":"Novel germline mutations of the MEN1 gene in Japanese patients with multiple endocrine neoplasia type 1","volume":"44","author":"Hamaguchi","year":"1999","journal-title":"J Hum Genet"},{"key":"10.1002\/humu.20605-BIB40","doi-asserted-by":"crossref","first-page":"3776","DOI":"10.1210\/jc.2003-031511","article-title":"Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma","volume":"89","author":"Hao","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ng0897-375","article-title":"Somatic mutation of the MEN1 gene in parathyroid tumours","volume":"16","author":"Heppner","year":"1997","journal-title":"Nat Genet"},{"key":"10.1002\/humu.20605-BIB42","doi-asserted-by":"crossref","first-page":"4917","DOI":"10.1038\/sj.onc.1204529","article-title":"The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation","volume":"20","author":"Heppner","year":"2001","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB43","first-page":"377","article-title":"Mutation of the multiple endocrine neoplasia type 1 gene in nonfamilial, malignant tumors of the endocrine pancreas","volume":"58","author":"Hessman","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB44","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/j.1460-2075.1989.tb03525.x","article-title":"Characterization of junD: a new member of the jun proto-oncogene family","volume":"8","author":"Hirai","year":"1989","journal-title":"EMBO J"},{"key":"10.1002\/humu.20605-BIB45","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/ng1403","article-title":"Nonsense-mediated decay approaches the clinic","volume":"36","author":"Holbrook","year":"2004","journal-title":"Nat Genet"},{"key":"10.1002\/humu.20605-BIB46","first-page":"301","article-title":"Nuclear\/cytoplasmic localization of the multiple endocrine neoplasia type 1 gene product, menin","volume":"79","author":"Huang","year":"1999","journal-title":"Lab Invest"},{"key":"10.1002\/humu.20605-BIB47","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1097-2765(04)00081-4","article-title":"Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus","volume":"13","author":"Hughes","year":"2004","journal-title":"Mol Cell"},{"key":"10.1002\/humu.20605-BIB48","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ejca.2006.08.038","article-title":"Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis","volume":"43","author":"Hussein","year":"2007","journal-title":"Eur J Cancer"},{"key":"10.1002\/humu.20605-BIB49","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mce.2006.02.008","article-title":"Characteristics of the Danish families with multiple endocrine neoplasia type 1","volume":"249","author":"Jager","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"10.1002\/humu.20605-BIB50","first-page":"4204","article-title":"Menin associates with FANCD2, a protein involved in repair of DNA damage","volume":"63","author":"Jin","year":"2003","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB51","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1073\/pnas.061358098","article-title":"Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling","volume":"98","author":"Kaji","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB52","doi-asserted-by":"crossref","first-page":"14659","DOI":"10.1073\/pnas.0503484102","article-title":"Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c","volume":"102","author":"Karnik","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB53","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/sj.ejhg.5201649","article-title":"Nonsense-mediated mRNA decay modulates clinical outcome of genetic disease","volume":"14","author":"Khajavi","year":"2006","journal-title":"Eur J Hum Genet"},{"key":"10.1002\/humu.20605-BIB54","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1006\/bbrc.2000.3471","article-title":"Heterogeneity at the 5\u2032-end of MEN1 transcripts","volume":"276","author":"Khodaei-O'Brien","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/humu.20605-BIB55","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1038\/sj.onc.1203005","article-title":"Stable overexpression of MEN1 suppresses tumorigenicity of RAS","volume":"18","author":"Kim","year":"1999","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB56","first-page":"6135","article-title":"Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex","volume":"63","author":"Kim","year":"2003","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB57","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB58","first-page":"113","article-title":"Heredity and cancer in man","volume":"9","author":"Knudson","year":"1973","journal-title":"Prog Med Genet"},{"key":"10.1002\/humu.20605-BIB59","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.molmed.2006.05.005","article-title":"Applying nonsense-mediated mRNA decay research to the clinic: progress and challenges","volume":"12","author":"Kuzmiak","year":"2006","journal-title":"Trends Mol Med"},{"key":"10.1002\/humu.20605-BIB60","doi-asserted-by":"crossref","first-page":"49045","DOI":"10.1074\/jbc.M409358200","article-title":"Direct binding of DNA by tumor suppressor menin","volume":"279","author":"La","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.20605-BIB61","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1038\/sj.onc.1209400","article-title":"Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression","volume":"25","author":"La","year":"2006","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB62","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/340692a0","article-title":"GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours","volume":"340","author":"Landis","year":"1989","journal-title":"Nature"},{"key":"10.1002\/humu.20605-BIB63","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/332085a0","article-title":"Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma","volume":"332","author":"Larsson","year":"1988","journal-title":"Nature"},{"key":"10.1002\/humu.20605-BIB64","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/bbrc.2001.5405","article-title":"Menin interacts directly with the homeobox-containing protein Pem","volume":"286","author":"Lemmens","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/humu.20605-BIB65","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2265.2007.02806.x","article-title":"A novel MEN1 intronic mutation associated with multiple endocrine neoplasia type 1","volume":"66","author":"Lemos","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1002\/humu.20605-BIB66","first-page":"OC22","article-title":"Mice deleted for a multiple endocrine neoplasia type 1 (MEN1) allele develop pancreatic, pituitary and parathyroid tumours in association with hypercalcaemia","volume":"13","author":"Lemos","year":"2007","journal-title":"Endocrine Abstracts"},{"key":"10.1002\/humu.20605-BIB67","first-page":"P199A","article-title":"Genetic background influences expression of multiple endocrine neoplasia type 1 (MEN1) mutation, implicating a role for genetic modifiers","volume":"13","author":"Lemos","year":"2007","journal-title":"Endocrine Abstracts"},{"key":"10.1002\/humu.20605-BIB68","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0092-8674(03)00430-6","article-title":"Multiple tumor suppressor pathways negatively regulate telomerase","volume":"113","author":"Lin","year":"2003","journal-title":"Cell"},{"key":"10.1002\/humu.20605-BIB69","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S1040-8428(84)80017-7","article-title":"Multiple endocrine neoplasia syndromes","volume":"2","author":"Lips","year":"1984","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1002\/humu.20605-BIB70","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/ijc.22288","article-title":"Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1","volume":"120","author":"Loffler","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1002\/humu.20605-BIB71","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1006\/excr.2002.5575","article-title":"Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity","volume":"278","author":"Lopez-Egido","year":"2002","journal-title":"Exp Cell Res"},{"key":"10.1002\/humu.20605-BIB72","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1507\/endocrj.46.539","article-title":"Loss of wild-type MEN1 gene expression in multiple endocrine neoplasia type 1-associated parathyroid adenoma","volume":"46","author":"Ludwig","year":"1999","journal-title":"Endocr J"},{"key":"10.1002\/humu.20605-BIB73","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1126\/science.2116665","article-title":"Two G protein oncogenes in human endocrine tumors","volume":"249","author":"Lyons","year":"1990","journal-title":"Science"},{"key":"10.1002\/humu.20605-BIB74","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/clinchem\/45.1.29","article-title":"Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue","volume":"45","author":"Mailman","year":"1999","journal-title":"Clin Chem"},{"key":"10.1002\/humu.20605-BIB75","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7326\/0003-4819-129-6-199809150-00011","article-title":"Multiple endocrine neoplasia type 1: clinical and genetic topics","volume":"129","author":"Marx","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1002\/humu.20605-BIB76","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1530\/eje.0.1430047","article-title":"Frequency of somatic MEN1 gene mutations in monoclonal parathyroid tumours of patients with primary hyperparathyroidism","volume":"143","author":"Miedlich","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"10.1002\/humu.20605-BIB77","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1073\/pnas.0408836102","article-title":"Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors","volume":"102","author":"Milne","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB78","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1002\/1097-0215(20000815)87:4<463::AID-IJC1>3.0.CO;2-8","article-title":"Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the MEN1 gene in sporadic melanoma","volume":"87","author":"Nord","year":"2000","journal-title":"Int J Cancer"},{"key":"10.1002\/humu.20605-BIB79","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1038\/sj.onc.1206658","article-title":"Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain","volume":"22","author":"Obungu","year":"2003","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB80","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1006\/bbrc.2001.4723","article-title":"Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23","volume":"282","author":"Ohkura","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/humu.20605-BIB81","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/(SICI)1098-1004(1998)11:4<264::AID-HUMU2>3.0.CO;2-V","article-title":"Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland","volume":"11","author":"Olufemi","year":"1998","journal-title":"Hum Mutat"},{"key":"10.1002\/humu.20605-BIB82","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrg1327","article-title":"Genomic variants in exons and introns: identifying the splicing spoilers","volume":"5","author":"Pagani","year":"2004","journal-title":"Nat Rev Genet"},{"key":"10.1002\/humu.20605-BIB83","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1677\/erc.0.0060449","article-title":"Multiple endocrine neoplasia type 1","volume":"6","author":"Pannett","year":"1999","journal-title":"Endocr Relat Cancer"},{"key":"10.1002\/humu.20605-BIB84","first-page":"4371","article-title":"Somatic mutations in MEN type 1 tumors, consistent with the Knudson \u201ctwo-hit\u201d hypothesis","volume":"86","author":"Pannett","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB85","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras","volume":"76","author":"Pfarr","year":"1994","journal-title":"Cell"},{"key":"10.1002\/humu.20605-BIB86","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1210\/jcem.83.4.4859","article-title":"Molecular characterization of the MEN1 tumor suppressor gene in sporadic pituitary tumors","volume":"83","author":"Prezant","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB87","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1073\/pnas.86.5.1500","article-title":"jun-D: a third member of the jun gene family","volume":"86","author":"Ryder","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.20605-BIB88","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1067\/msy.2000.104165","article-title":"Somatic mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in patients with sporadic, nonfamilial primary hyperparathyroidism","volume":"127","author":"Sato","year":"2000","journal-title":"Surgery"},{"key":"10.1002\/humu.20605-BIB89","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/gene.1072","article-title":"Bidirectional transcriptional activity of PGK-neomycin and unexpected embryonic lethality in heterozygote chimeric knockout mice","volume":"30","author":"Scacheri","year":"2001","journal-title":"Genesis"},{"key":"10.1002\/humu.20605-BIB90","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1371\/journal.pgen.0020051","article-title":"Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis","volume":"2","author":"Scacheri","year":"2006","journal-title":"PLoS Genet"},{"key":"10.1002\/humu.20605-BIB91","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/(SICI)1096-9896(199906)188:2<168::AID-PATH342>3.0.CO;2-4","article-title":"Analysis of the MEN1 gene in sporadic pituitary adenomas","volume":"188","author":"Schmidt","year":"1999","journal-title":"J Pathol"},{"key":"10.1002\/humu.20605-BIB92","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1158\/0008-5472.CAN-04-0724","article-title":"Functional interaction between tumor suppressor menin and activator of S-phase kinase","volume":"64","author":"Schnepp","year":"2004","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB93","first-page":"471","article-title":"Somatic mutations of multiple endocrine neoplasia type 1 gene in the sporadic endocrine tumors","volume":"78","author":"Shan","year":"1998","journal-title":"Lab Invest"},{"key":"10.1002\/humu.20605-BIB94","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11102-005-0-04-0","article-title":"Isolated familial somatotropinoma","volume":"7","author":"Soares","year":"2004","journal-title":"Pituitary"},{"key":"10.1002\/humu.20605-BIB95","doi-asserted-by":"crossref","first-page":"6580","DOI":"10.1210\/jc.2005-1478","article-title":"Tumor deletion mapping on chromosome 11q13 in eight families with isolated familial somatotropinoma and in 15 sporadic somatotropinomas","volume":"90","author":"Soares","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB96","doi-asserted-by":"crossref","first-page":"21058","DOI":"10.1074\/jbc.M302044200","article-title":"Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage","volume":"278","author":"Sowa","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.20605-BIB97","doi-asserted-by":"crossref","first-page":"40267","DOI":"10.1074\/jbc.M401312200","article-title":"Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2","volume":"279","author":"Sowa","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.20605-BIB98","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1210\/jc.2003-031228","article-title":"Transfection of the multiple endocrine neoplasia type 1 gene to a human endocrine pancreatic tumor cell line inhibits cell growth and affects expression of JunD, delta-like protein 1\/preadipocyte factor-1, proliferating cell nuclear antigen, and QM\/Jif-1","volume":"89","author":"Stalberg","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB99","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1038\/sj.onc.1202164","article-title":"Characterization of the mouse Men1 gene and its expression during development","volume":"17","author":"Stewart","year":"1998","journal-title":"Oncogene"},{"key":"10.1002\/humu.20605-BIB100","first-page":"4776","article-title":"Pituitary macroadenoma in a 5-year-old: an early expression of multiple endocrine neoplasia type 1","volume":"85","author":"Stratakis","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB101","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/MCB.23.2.493-509.2003","article-title":"The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene","volume":"23","author":"Sukhodolets","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.20605-BIB102","first-page":"2631","article-title":"Analysis of loss of heterozygosity on chromosome 11 and infrequent inactivation of the MEN1 gene in sporadic pituitary adenomas","volume":"83","author":"Tanaka","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB103","first-page":"2621","article-title":"Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism","volume":"83","author":"Teh","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB104","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1056\/NEJM198907273210403","article-title":"Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11","volume":"321","author":"Thakker","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1002\/humu.20605-BIB105","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1172\/JCI116524","article-title":"Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations","volume":"91","author":"Thakker","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1002\/humu.20605-BIB106","first-page":"2617","article-title":"Multiple endocrine neoplasia-syndromes of the twentieth century","volume":"83","author":"Thakker","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB107","first-page":"3509","volume-title":"Endocrinology","author":"Thakker","year":"2006"},{"key":"10.1002\/humu.20605-BIB108","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/qjmed\/89.9.653","article-title":"Clinical studies of multiple endocrine neoplasia type 1 (MEN1)","volume":"89","author":"Trump","year":"1996","journal-title":"QJM"},{"key":"10.1002\/humu.20605-BIB109","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1210\/jcem.87.6.8607","article-title":"Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1","volume":"87","author":"Turner","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1002\/humu.20605-BIB110","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1126\/science.1126100","article-title":"Pituitary adenoma predisposition caused by germline mutations in the AIP gene","volume":"312","author":"Vierimaa","year":"2006","journal-title":"Science"},{"key":"10.1002\/humu.20605-BIB111","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/eje.0.1470313","article-title":"Involvement of the MEN1 gene locus in familial isolated hyperparathyroidism","volume":"147","author":"Villablanca","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"10.1002\/humu.20605-BIB112","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/jnci\/90.5.398","article-title":"Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas","volume":"90","author":"Vortmeyer","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1002\/humu.20605-BIB113","first-page":"4417","article-title":"Mutation of the MENIN gene in sporadic pancreatic endocrine tumors","volume":"58","author":"Wang","year":"1998","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB114","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0002-9343(54)90353-8","article-title":"Genetic aspects of adenomatosis of endocrine glands","volume":"16","author":"Wermer","year":"1954","journal-title":"Am J Med"},{"key":"10.1002\/humu.20605-BIB115","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1001\/archsurg.1993.01420180085016","article-title":"Cause of death in multiple endocrine neoplasia type 1","volume":"128","author":"Wilkinson","year":"1993","journal-title":"Arch Surg"},{"key":"10.1002\/humu.20605-BIB116","doi-asserted-by":"crossref","first-page":"38197","DOI":"10.1074\/jbc.M204132200","article-title":"Menin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23","volume":"277","author":"Yaguchi","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.20605-BIB117","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1128\/MCB.24.15.6569-6580.2004","article-title":"Menin missense mutants associated with multiple endocrine neoplasia type 1 are rapidly degraded via the ubiquitin-proteasome pathway","volume":"24","author":"Yaguchi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.20605-BIB118","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1128\/MCB.24.13.5639-5649.2004","article-title":"Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression","volume":"24","author":"Yokoyama","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.20605-BIB119","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1002\/ijc.10885","article-title":"Suppression of insulin-induced AP-1 transactivation by menin accompanies inhibition of c-Fos induction","volume":"103","author":"Yumita","year":"2003","journal-title":"Int J Cancer"},{"key":"10.1002\/humu.20605-BIB120","first-page":"4682","article-title":"Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"},{"key":"10.1002\/humu.20605-BIB121","first-page":"5446","article-title":"Mutations of the MEN1 tumor suppressor gene in pituitary tumors","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.20605","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/humu.20605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:51:02Z","timestamp":1672314662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.20605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":121,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"URL":"https:\/\/doi.org\/10.1002\/humu.20605","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1095906.551855","asserted-by":"object"}]},"ISSN":["1059-7794","1098-1004"],"issn-type":[{"value":"1059-7794","type":"print"},{"value":"1098-1004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}