{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:26:43Z","timestamp":1790879203703,"version":"4.1.0"},"reference-count":60,"publisher":"Hindawi Limited","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1680,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mutat."],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1002\/humu.21419","type":"journal-article","created":{"date-parts":[[2010,11,30]],"date-time":"2010-11-30T20:21:27Z","timestamp":1291148487000},"page":"220-230","source":"Crossref","is-referenced-by-count":42,"title":["SMN2 exon 7 splicing is inhibited by binding of hnRNP A1 to a common ESS motif that spans the 3\u2032 splice site"],"prefix":"10.1155","volume":"32","author":[{"given":"Thomas","family":"Koed Doktor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisbeth Dahl","family":"Schroeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Vested","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Palmfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henriette Skovgaard","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Gregersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brage Storstein","family":"Andresen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","published-online":{"date-parts":[[2011,1,25]]},"reference":[{"key":"10.1002\/humu.21419-BIB1|cit1","doi-asserted-by":"crossref","first-page":"4063","DOI":"10.1093\/nar\/24.20.4063","article-title":"hnRNP A1 binds promiscuously to oligoribonucleotides: utilization of random and homo-oligonucleotides to discriminate sequence from base-specific binding","volume":"24","author":"Abdul-Manan","year":"1996","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB2|cit2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.genet.36.043002.091635","article-title":"Allosteric cascade of spliceosome activation","volume":"36","author":"Brow","year":"2002","journal-title":"Annu Rev Genet"},{"key":"10.1002\/humu.21419-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1002\/j.1460-2075.1994.tb06369.x","article-title":"RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing","volume":"13","author":"Burd","year":"1994","journal-title":"EMBO J"},{"key":"10.1002\/humu.21419-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1128\/MCB.01262-08","article-title":"Regulation of SMN protein stability","volume":"29","author":"Burnett","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB5|cit5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.nbd.2007.04.009","article-title":"Abnormal motor phenotype in the SMNDelta7 mouse model of spinal muscular atrophy","volume":"27","author":"Butchbach","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1002\/humu.21419-BIB6|cit6","doi-asserted-by":"crossref","first-page":"6595","DOI":"10.1093\/nar\/18.22.6595","article-title":"Recombinant hnRNP protein A1 and its N-terminal domain show preferential affinity for oligodeoxynucleotides homologous to intron\/exon acceptor sites","volume":"18","author":"Buvoli","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB7|cit7","doi-asserted-by":"crossref","first-page":"43850","DOI":"10.1074\/jbc.M102861200","article-title":"Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H\/H'\/F\/2H9 family","volume":"276","author":"Caputi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.21419-BIB8|cit8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrg775","article-title":"Listening to silence and understanding nonsense: exonic mutations that affect splicing","volume":"3","author":"Cartegni","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1002\/humu.21419-BIB9|cit9","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1086\/498853","article-title":"Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2","volume":"78","author":"Cartegni","year":"2006","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB10|cit10","doi-asserted-by":"crossref","first-page":"3568","DOI":"10.1093\/nar\/gkg616","article-title":"ESEfinder: A web resource to identify exonic splicing enhancers","volume":"31","author":"Cartegni","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB11|cit11","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1101\/gad.1884910","article-title":"A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity","volume":"24","author":"Cho","year":"2010","journal-title":"Genes Dev"},{"key":"10.1002\/humu.21419-BIB12|cit12","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1128\/MCB.17.4.2143","article-title":"Identification of a new class of exonic splicing enhancers by in vivo selection","volume":"17","author":"Coulter","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB13|cit13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/nbdi.1996.0010","article-title":"The neurobiology of childhood spinal muscular atrophy","volume":"3","author":"Crawford","year":"1996","journal-title":"Neurobiol Dis"},{"key":"10.1002\/humu.21419-BIB14|cit14","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1093\/nar\/gkp215","article-title":"Human Splicing Finder: an online bioinformatics tool to predict splicing signals","volume":"37","author":"Desmet","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB15|cit15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.ymgme.2010.04.002","article-title":"The phenylalanine hydroxylase c.30C>G synonymous variation (p.G10G) creates a common exonic splicing silencer","volume":"100","author":"Dobrowolski","year":"2010","journal-title":"Mol Genet Metab"},{"key":"10.1002\/humu.21419-BIB16|cit16","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1128\/MCB.23.23.8762-8772.2003","article-title":"Human immunodeficiency virus type 1 hnRNP A\/B-dependent exonic splicing silencer ESSV antagonizes binding of U2AF65 to viral polypyrimidine tracts","volume":"23","author":"Domsic","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB17|cit17","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/338627","article-title":"Quantitative analyses of SMN1 and SMN2 based on real-time lightCycler PCR: fast and highly reliable carrier testing and prediction of severity of spinal muscular atrophy","volume":"70","author":"Feldkotter","year":"2002","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB18|cit18","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1017\/S1355838201010317","article-title":"The role of U2AF35 and U2AF65 in enhancer-dependent splicing","volume":"7","author":"Graveley","year":"2001","journal-title":"RNA"},{"key":"10.1002\/humu.21419-BIB19|cit19","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuroscience.2008.01.070","article-title":"Decreased expression of the mitochondrial matrix proteases Lon and ClpP in cells from a patient with hereditary spastic paraplegia (SPG13)","volume":"153","author":"Hansen","year":"2008","journal-title":"Neuroscience"},{"key":"10.1002\/humu.21419-BIB20|cit20","doi-asserted-by":"crossref","first-page":"e538","DOI":"10.1371\/journal.pone.0000538","article-title":"Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF65","volume":"2","author":"Hastings","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1002\/humu.21419-BIB21|cit21","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1101\/gad.1941310","article-title":"Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model","volume":"24","author":"Hua","year":"2010","journal-title":"Genes Dev"},{"key":"10.1002\/humu.21419-BIB22|cit22","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1371\/journal.pbio.0050073","article-title":"Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon","volume":"5","author":"Hua","year":"2007","journal-title":"PLoS Biol"},{"key":"10.1002\/humu.21419-BIB23|cit23","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ajhg.2008.01.014","article-title":"Antisense masking of an hnRNP A1\/A2 intronic splicing silencer corrects SMN2 splicing in transgenic mice","volume":"82","author":"Hua","year":"2008","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB24|cit24","doi-asserted-by":"crossref","first-page":"D493","DOI":"10.1093\/nar\/gkh103","article-title":"The UCSC Table Browser data retrieval tool","volume":"32","author":"Karolchik","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB25|cit25","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/ng1207","article-title":"A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy","volume":"34","author":"Kashima","year":"2003","journal-title":"Nat Genet"},{"key":"10.1002\/humu.21419-BIB26|cit26","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1093\/hmg\/ddm276","article-title":"hnRNP A1 functions with specificity in repression of SMN2 exon 7 splicing","volume":"16","author":"Kashima","year":"2007a","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB27|cit27","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1073\/pnas.0700343104","article-title":"An intronic element contributes to splicing repression in spinal muscular atrophy","volume":"104","author":"Kashima","year":"2007b","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.21419-BIB28|cit28","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/MCB.25.1.233-240.2005","article-title":"Characterization of a U2AF-independent commitment complex (E') in the mammalian spliceosome assembly pathway","volume":"25","author":"Kent","year":"2005","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB29|cit29","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1074\/jbc.M305623200","article-title":"Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease","volume":"279","author":"Kikuchi","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.21419-BIB30|cit30","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB31|cit31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"10.1002\/humu.21419-BIB32|cit32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and SMN protein level in spinal muscular atrophy","volume":"16","author":"Lefebvre","year":"1997","journal-title":"Nat Genet"},{"key":"10.1002\/humu.21419-BIB33|cit33","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1086\/511527","article-title":"The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior","volume":"80","author":"Lenski","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB34|cit34","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/hmg\/9.2.259","article-title":"An exonic enhancer is required for inclusion of an essential exon in the SMA-determining gene SMN","volume":"9","author":"Lorson","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB35|cit35","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1261\/rna.1273209","article-title":"Differential 3\u2032 splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP","volume":"15","author":"Martins de Araujo","year":"2009","journal-title":"RNA"},{"key":"10.1002\/humu.21419-BIB36|cit36","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1093\/hmg\/ddn305","article-title":"hnRNP H enhances skipping of a nonfunctional exon P3A in CHRNA1 and a mutation disrupting its binding causes congenital myasthenic syndrome","volume":"17","author":"Masuda","year":"2008","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB37|cit37","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1128\/MCB.13.5.2993","article-title":"Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2\/ASF","volume":"13","author":"Mayeda","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB38|cit38","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/45602","article-title":"Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3\u2032 splice site AG","volume":"402","author":"Merendino","year":"1999","journal-title":"Nature"},{"key":"10.1002\/humu.21419-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"Monani","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB40|cit40","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1086\/511992","article-title":"Seemingly neutral polymorphic variants may confer immunity to splicing-inactivating mutations: a synonymous SNP in exon 5 of MCAD protects from deleterious mutations in a flanking exonic splicing enhancer","volume":"80","author":"Nielsen","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB41|cit41","doi-asserted-by":"crossref","first-page":"5620","DOI":"10.1128\/MCB.01678-08","article-title":"Cooperative-binding and splicing-repressive properties of hnRNP A1","volume":"29","author":"Okunola","year":"2009","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/emboj.2010.19","article-title":"The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy","volume":"29","author":"Pedrotti","year":"2010","journal-title":"EMBO J"},{"key":"10.1002\/humu.21419-BIB43|cit43","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1002\/humu.21419-BIB44|cit44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/cmb.1997.4.311","article-title":"Improved splice site detection in Genie","volume":"4","author":"Reese","year":"1997","journal-title":"J Comput Biol"},{"key":"10.1002\/humu.21419-BIB45|cit45","doi-asserted-by":"crossref","first-page":"D613","DOI":"10.1093\/nar\/gkp939","article-title":"The UCSC Genome Browser database: update 2010","volume":"38","author":"Rhead","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB46|cit46","first-page":"404","article-title":"The \u201cmegaprimer\u201d method of site-directed mutagenesis","volume":"8","author":"Sarkar","year":"1990","journal-title":"Biotechniques"},{"key":"10.1002\/humu.21419-BIB47|cit47","doi-asserted-by":"crossref","first-page":"13617","DOI":"10.1074\/jbc.M700774200","article-title":"Members of the heterogeneous nuclear ribonucleoprotein H family activate splicing of an HIV-1 splicing substrate by promoting formation of ATP-dependent spliceosomal complexes","volume":"282","author":"Schaub","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.21419-BIB48|cit48","doi-asserted-by":"crossref","first-page":"3955","DOI":"10.1093\/nar\/gkl556","article-title":"Comprehensive splice-site analysis using comparative genomics","volume":"34","author":"Sheth","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21419-BIB49|cit49","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.bbrc.2004.01.067","article-title":"An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy","volume":"315","author":"Singh","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/humu.21419-BIB50|cit50","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1128\/MCB.8.5.2237","article-title":"Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificities","volume":"8","author":"Swanson","year":"1988a","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21419-BIB51|cit51","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1002\/j.1460-2075.1988.tb03228.x","article-title":"RNA binding specificity of hnRNP proteins: a subset bind to the 3\u2032 end of introns","volume":"7","author":"Swanson","year":"1988b","journal-title":"EMBO J"},{"key":"10.1002\/humu.21419-BIB52|cit52","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/hmg\/5.2.257","article-title":"Molecular analysis of the SMN and NAIP genes in Spanish spinal muscular atrophy (SMA) families and correlation between number of copies of cBCD541 and SMA phenotype","volume":"5","author":"Velasco","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21419-BIB53|cit53","doi-asserted-by":"crossref","first-page":"9203","DOI":"10.1073\/pnas.0900342106","article-title":"The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing","volume":"106","author":"Warf","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.21419-BIB54|cit54","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1086\/302369","article-title":"Quantitative analysis of survival motor neuron copies: identification of subtle SMN1 mutations in patients with spinal muscular atrophy, genotype-phenotype correlation, and implications for genetic counseling","volume":"64","author":"Wirth","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21419-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0092-8674(93)90316-I","article-title":"Specific interactions between proteins implicated in splice site selection and regulated alternative splicing","volume":"75","author":"Wu","year":"1993","journal-title":"Cell"},{"key":"10.1002\/humu.21419-BIB56|cit56","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/45996","article-title":"Functional recognition of the 3\u2032 splice site AG by the splicing factor U2AF35","volume":"402","author":"Wu","year":"1999","journal-title":"Nature"},{"key":"10.1002\/humu.21419-BIB57|cit57","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/1066527041410418","article-title":"Maximum entropy modeling of short sequence motifs with applications to RNA splicing signals","volume":"11","author":"Yeo","year":"2004","journal-title":"J Comput Biol"},{"key":"10.1002\/humu.21419-BIB58|cit58","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/355609a0","article-title":"Cloning and domain structure of the mammalian splicing factor U2AF","volume":"355","author":"Zamore","year":"1992","journal-title":"Nature"},{"key":"10.1002\/humu.21419-BIB59|cit59","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/humu.20103","article-title":"Disruption of exonic splicing enhancer elements is the principal cause of exon skipping associated with seven nonsense or missense alleles of NF1","volume":"24","author":"Zatkova","year":"2004","journal-title":"Hum Mutat"},{"key":"10.1002\/humu.21419-BIB60|cit60","doi-asserted-by":"crossref","first-page":"8769","DOI":"10.1073\/pnas.89.18.8769","article-title":"Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit","volume":"89","author":"Zhang","year":"1992","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.21419","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1002\/humu.21419\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:52:05Z","timestamp":1672332725000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.21419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,25]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1002\/humu.21419","relation":{},"ISSN":["1059-7794"],"issn-type":[{"value":"1059-7794","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1,25]]}}}