{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:51:34Z","timestamp":1791111094566,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1575,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Mutat."],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1002\/humu.21508","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T18:29:45Z","timestamp":1303410585000},"page":"806-814","source":"Crossref","is-referenced-by-count":23,"title":["Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans"],"prefix":"10.1155","volume":"32","author":[{"given":"Margus","family":"Putku","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Kepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Org","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siim","family":"S\u00f5ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Comas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margus","family":"Viigimaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Veldre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peeter","family":"Juhanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pille","family":"Hallast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeme","family":"T\u00f5nisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HYPEST","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Shaw-Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Caulfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"BRIGHT","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elza","family":"Khusnutdinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktor","family":"Ko\u017eich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia B.","family":"Munroe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maris","family":"Laan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,5,10]]},"reference":[{"key":"10.1002\/humu.21508-BIB1|cit1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrg798","article-title":"Alu repeats and human genomic diversity","volume":"3","author":"Batzer","year":"2002","journal-title":"Nat Rev Genet"},{"key":"10.1002\/humu.21508-BIB2|cit2","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1371\/journal.pgen.0030066","article-title":"Genetic structure of chimpanzee populations","volume":"3","author":"Becquet","year":"2007","journal-title":"PLoS Genet"},{"key":"10.1002\/humu.21508-BIB3|cit3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1101\/gr.5558208","article-title":"Mammalian non-LTR retrotransposons: for better or worse, in sickness and in health","volume":"18","author":"Belancio","year":"2008","journal-title":"Genome Res"},{"key":"10.1002\/humu.21508-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1101\/gr.081737.108","article-title":"Active Alu retrotransposons in the human genome","volume":"18","author":"Bennett","year":"2008","journal-title":"Genome Res"},{"key":"10.1002\/humu.21508-BIB5|cit5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biochem.72.121801.161720","article-title":"Mechanisms of alternative pre-messenger RNA splicing","volume":"72","author":"Black","year":"2003","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/humu.21508-BIB6|cit6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000092503","article-title":"Retrotransposable elements and human disease","volume":"1","author":"Callinan","year":"2006","journal-title":"Genome Dis"},{"key":"10.1002\/humu.21508-BIB7|cit7","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1016\/S0140-6736(03)13722-1","article-title":"Genome-wide mapping of human loci for essential hypertension","volume":"361","author":"Caulfield","year":"2003","journal-title":"Lancet"},{"key":"10.1002\/humu.21508-BIB8|cit8","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s004390000370","article-title":"Alu insertion polymorphisms in NW Africa and the Iberian Peninsula: evidence for a strong genetic boundary through the Gibraltar Straits","volume":"107","author":"Comas","year":"2000","journal-title":"Hum Genet"},{"key":"10.1002\/humu.21508-BIB9|cit9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg2640","article-title":"The impact of retrotransposons on human genome evolution","volume":"10","author":"Cordaux","year":"2009","journal-title":"Nat Rev Genet"},{"key":"10.1002\/humu.21508-BIB10|cit10","doi-asserted-by":"crossref","first-page":"9208","DOI":"10.1128\/MCB.23.24.9208-9221.2003","article-title":"Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform","volume":"23","author":"Delaloy","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1002\/humu.21508-BIB11|cit11","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.tig.2008.04.005","article-title":"Tuning in to the signals: noncoding sequence conservation in vertebrate genomes","volume":"24","author":"Elgar","year":"2008","journal-title":"Trends Genet"},{"key":"10.1002\/humu.21508-BIB12|cit12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.jmb.2004.04.033","article-title":"Distinguishing humans from great apes with AluYb8 repeats","volume":"339","author":"Gibbons","year":"2004","journal-title":"J Mol Biol"},{"key":"10.1002\/humu.21508-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1101\/gr.4270505","article-title":"Segmental duplications and gene conversion: human luteinizing hormone\/chorionic gonadotropin beta gene cluster","volume":"15","author":"Hallast","year":"2005","journal-title":"Genome Res"},{"key":"10.1002\/humu.21508-BIB14|cit14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0168-9525(00)02081-3","article-title":"Conserved noncoding sequences are reliable guides to regulatory elements","volume":"16","author":"Hardison","year":"2000","journal-title":"Trends Genet"},{"key":"10.1002\/humu.21508-BIB15|cit15","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.1093\/nar\/gkl706","article-title":"Alu elements as regulators of gene expression","volume":"34","author":"Hasler","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/humu.21508-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1161\/01.CIR.101.17.2060","article-title":"Deletion allele of angiotensin-converting enzyme gene increases risk of essential hypertension in Japanese men: the Suita Study","volume":"101","author":"Higaki","year":"2000","journal-title":"Circulation"},{"key":"10.1002\/humu.21508-BIB17|cit17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1096-7192(03)00079-9","article-title":"Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease","volume":"79","author":"Janosikova","year":"2003","journal-title":"Mol Genet Metab"},{"key":"10.1002\/humu.21508-BIB18|cit18","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/ng.118","article-title":"Rare independent mutations in renal salt handling genes contribute to blood pressure variation","volume":"40","author":"Ji","year":"2008","journal-title":"Nat Genet"},{"key":"10.1002\/humu.21508-BIB19|cit19","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s10038-004-0181-0","article-title":"Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population","volume":"49","author":"Kokubo","year":"2004","journal-title":"J Hum Genet"},{"key":"10.1002\/humu.21508-BIB20|cit20","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0092-8674(01)00241-0","article-title":"Molecular mechanisms of human hypertension","volume":"104","author":"Lifton","year":"2001","journal-title":"Cell"},{"key":"10.1002\/humu.21508-BIB21|cit21","first-page":"1372","article-title":"Processing of gene expression data generated by quantitative real-time RT-PCR","volume":"32","author":"Muller","year":"2002","journal-title":"Biotechniques"},{"key":"10.1002\/humu.21508-BIB22|cit22","doi-asserted-by":"crossref","first-page":"e5003","DOI":"10.1371\/journal.pone.0005003","article-title":"Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion","volume":"4","author":"Newhouse","year":"2009","journal-title":"PLoS One"},{"key":"10.1002\/humu.21508-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1093\/hmg\/ddi187","article-title":"Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study","volume":"14","author":"Newhouse","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1002\/humu.21508-BIB24|cit24","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1161\/01.CIR.97.18.1766","article-title":"Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study","volume":"97","author":"O'Donnell","year":"1998","journal-title":"Circulation"},{"key":"10.1002\/humu.21508-BIB25|cit25","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/jhg.2009.64","article-title":"Variations in the WNK1 gene modulates the effect of dietary intake of sodium and potassium on blood pressure determination","volume":"54","author":"Osada","year":"2009","journal-title":"J Hum Genet"},{"key":"10.1002\/humu.21508-BIB26|cit26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/HJH.0b013e32833594d7","article-title":"The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study","volume":"28","author":"Padmanabhan","year":"2010","journal-title":"J Hypertens"},{"key":"10.1002\/humu.21508-BIB27|cit27","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1126\/science.1101659","article-title":"Cis-acting regulatory variation in the human genome","volume":"306","author":"Pastinen","year":"2004","journal-title":"Science"},{"key":"10.1002\/humu.21508-BIB28|cit28","doi-asserted-by":"crossref","first-page":"e155","DOI":"10.1371\/journal.pbio.0020155","article-title":"Absence of the TAP2 human recombination hotspot in chimpanzees","volume":"2","author":"Ptak","year":"2004","journal-title":"PLoS Biol"},{"key":"10.1002\/humu.21508-BIB29|cit29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0168-9525(00)02024-2","article-title":"EMBOSS: the European Molecular Biology Open Software Suite","volume":"16","author":"Rice","year":"2000","journal-title":"Trends Genet"},{"key":"10.1002\/humu.21508-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI114844","article-title":"An insertion\/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels","volume":"86","author":"Rigat","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1002\/humu.21508-BIB31|cit31","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol Biol"},{"key":"10.1002\/humu.21508-BIB32|cit32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s00424-007-0308-1","article-title":"Gender differences in kidney function","volume":"455","author":"Sabolic","year":"2007","journal-title":"Pflugers Arch"},{"key":"10.1002\/humu.21508-BIB33|cit33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/00365510260390028","article-title":"Angiotensin I-converting enzyme gene polymorphism in a Serbian population: a gender-specific association with hypertension","volume":"62","author":"Stankovic","year":"2002","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1002\/humu.21508-BIB34|cit34","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1161\/CIRCULATIONAHA.105.555474","article-title":"Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population","volume":"112","author":"Tobin","year":"2005","journal-title":"Circulation"},{"key":"10.1002\/humu.21508-BIB35|cit35","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1161\/HYPERTENSIONAHA.108.118414","article-title":"Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children","volume":"52","author":"Tobin","year":"2008","journal-title":"Hypertension"},{"key":"10.1002\/humu.21508-BIB36|cit36","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.HYP.0000186240.81996.57","article-title":"WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic","volume":"46","author":"Turner","year":"2005","journal-title":"Hypertension"},{"key":"10.1002\/humu.21508-BIB37|cit37","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00467-007-0537-8","article-title":"Heritable forms of hypertension","volume":"24","author":"Vehaskari","year":"2007","journal-title":"Pediatr Nephrol"},{"key":"10.1002\/humu.21508-BIB38|cit38","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1038\/sj.onc.1204726","article-title":"WNK kinases, a novel protein kinase subfamily in multi-cellular organisms","volume":"20","author":"Verissimo","year":"2001","journal-title":"Oncogene"},{"key":"10.1002\/humu.21508-BIB39|cit39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature08451","article-title":"Genomic views of distant-acting enhancers","volume":"461","author":"Visel","year":"2009","journal-title":"Nature"},{"key":"10.1002\/humu.21508-BIB40|cit40","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1086\/318793","article-title":"Patterns of ancestral human diversity: an analysis of Alu-insertion and restriction-site polymorphisms","volume":"68","author":"Watkins","year":"2001","journal-title":"Am J Hum Genet"},{"key":"10.1002\/humu.21508-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1101\/gr.894603","article-title":"Genetic variation among world populations: inferences from 100 Alu insertion polymorphisms","volume":"13","author":"Watkins","year":"2003","journal-title":"Genome Res"},{"key":"10.1002\/humu.21508-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1126\/science.1062844","article-title":"Human hypertension caused by mutations in WNK kinases","volume":"293","author":"Wilson","year":"2001","journal-title":"Science"},{"key":"10.1002\/humu.21508-BIB43|cit43","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1073\/pnas.242735399","article-title":"Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4","volume":"100","author":"Wilson","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/humu.21508-BIB44|cit44","doi-asserted-by":"crossref","first-page":"16795","DOI":"10.1074\/jbc.275.22.16795","article-title":"WNK1, a novel mammalian serine\/threonine protein kinase lacking the catalytic lysine in subdomain II","volume":"275","author":"Xu","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1002\/humu.21508-BIB45|cit45","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1093\/nar\/gkf492","article-title":"Genome-wide detection of tissue-specific alternative splicing in the human transcriptome","volume":"30","author":"Xu","year":"2002","journal-title":"Nucleic Acids Res"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.21508","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1002\/humu.21508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:52:30Z","timestamp":1672332750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.21508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5,10]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2011,7]]}},"URL":"https:\/\/doi.org\/10.1002\/humu.21508","relation":{},"ISSN":["1059-7794"],"issn-type":[{"value":"1059-7794","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5,10]]}}}