{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:24:01Z","timestamp":1784697841897,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["NIH U01 GM115486"],"award-info":[{"award-number":["NIH U01 GM115486"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002001","name":"Health Services and Delivery Research Programme","doi-asserted-by":"publisher","award":["NIH R01 MH115958 01"],"award-info":[{"award-number":["NIH R01 MH115958 01"]}],"id":[{"id":"10.13039\/501100002001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Mutation"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1002\/humu.23832","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T15:49:31Z","timestamp":1562168971000},"page":"1486-1494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["What went wrong with variant effect predictor performance for the PCM1 challenge"],"prefix":"10.1155","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-9499","authenticated-orcid":false,"given":"Maximilian","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Biochemistry and MicrobiologyRutgers University New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanran","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and MicrobiologyRutgers University New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8351-0844","authenticated-orcid":false,"given":"Yana","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and MicrobiologyRutgers University New Brunswick New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"e_1_2_6_1_2_1","first-page":"20","article-title":"Predicting functional effect of human missense mutations using PolyPhen\u20102","volume":"9999","author":"Adzhubei I.","year":"2013","journal-title":"Current Protocols in Human Genetics"},{"key":"e_1_2_6_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth0410-248"},{"key":"e_1_2_6_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw408"},{"key":"e_1_2_6_1_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.187302"},{"key":"e_1_2_6_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-3167-5_2"},{"key":"e_1_2_6_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216613110"},{"key":"e_1_2_6_1_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm238"},{"key":"e_1_2_6_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn435"},{"key":"e_1_2_6_1_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-S3-S3"},{"key":"e_1_2_6_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv195"},{"key":"e_1_2_6_1_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.092619.109"},{"key":"e_1_2_6_1_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200204023"},{"key":"e_1_2_6_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.128"},{"key":"e_1_2_6_1_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1001025"},{"key":"e_1_2_6_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp190"},{"key":"e_1_2_6_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484077"},{"key":"e_1_2_6_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2534"},{"key":"e_1_2_6_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts336"},{"key":"e_1_2_6_1_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.844"},{"key":"e_1_2_6_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.03.024"},{"key":"e_1_2_6_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2016.08.006"},{"key":"e_1_2_6_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2315-x"},{"key":"e_1_2_6_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3703"},{"key":"e_1_2_6_1_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1055"},{"key":"e_1_2_6_1_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.65.9.996"},{"key":"e_1_2_6_1_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/27.1.355"},{"key":"e_1_2_6_1_28_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI57552"},{"key":"e_1_2_6_1_29_1","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2018.38.5.492"},{"key":"e_1_2_6_1_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1039"},{"key":"e_1_2_6_1_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10576"},{"key":"e_1_2_6_1_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40246-017-0104-8"},{"key":"e_1_2_6_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41329"},{"key":"e_1_2_6_1_34_1","first-page":"578757","article-title":"fuNTRp: Identifying protein positions for variation driven functional tuning","author":"Miller M.","year":"2019","journal-title":"bioRxiv"},{"key":"e_1_2_6_1_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511585112"},{"key":"e_1_2_6_1_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31088"},{"key":"e_1_2_6_1_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg509"},{"key":"e_1_2_6_1_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1189"},{"key":"e_1_2_6_1_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313250"},{"key":"e_1_2_6_1_40_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.097857.109"},{"key":"e_1_2_6_1_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu703"},{"key":"e_1_2_6_1_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1016"},{"key":"e_1_2_6_1_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr407"},{"key":"e_1_2_6_1_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340190108"},{"key":"e_1_2_6_1_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(81)90087-5"},{"key":"e_1_2_6_1_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21445"},{"key":"e_1_2_6_1_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1711-3"},{"key":"e_1_2_6_1_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky092"},{"key":"e_1_2_6_1_49_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.12950"},{"key":"e_1_2_6_1_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku366"},{"key":"e_1_2_6_1_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2015.02.002"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhumu.23832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/humu.23832","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/humu.23832","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/humu.23832","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:53:51Z","timestamp":1672332831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.23832"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/humu.23832"],"URL":"https:\/\/doi.org\/10.1002\/humu.23832","archive":["Portico"],"relation":{},"ISSN":["1059-7794","1098-1004"],"issn-type":[{"value":"1059-7794","type":"print"},{"value":"1098-1004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"2019-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}