{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T03:15:57Z","timestamp":1777950957077,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,9,15]],"date-time":"2019-09-15T00:00:00Z","timestamp":1568505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["WA1477\/6\u20102"],"award-info":[{"award-number":["WA1477\/6\u20102"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01ET1006B"],"award-info":[{"award-number":["01ET1006B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0102"],"award-info":[{"award-number":["01GI0102"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0420"],"award-info":[{"award-number":["01GI0420"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0422"],"award-info":[{"award-number":["01GI0422"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0423"],"award-info":[{"award-number":["01GI0423"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0429"],"award-info":[{"award-number":["01GI0429"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0431"],"award-info":[{"award-number":["01GI0431"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0433"],"award-info":[{"award-number":["01GI0433"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0434"],"award-info":[{"award-number":["01GI0434"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0710"],"award-info":[{"award-number":["01GI0710"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0711"],"award-info":[{"award-number":["01GI0711"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0712"],"award-info":[{"award-number":["01GI0712"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0713"],"award-info":[{"award-number":["01GI0713"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0714"],"award-info":[{"award-number":["01GI0714"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0715"],"award-info":[{"award-number":["01GI0715"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01GI0716"],"award-info":[{"award-number":["01GI0716"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010146","name":"Alzheimer Forschung Initiative","doi-asserted-by":"publisher","award":["16019"],"award-info":[{"award-number":["16019"]}],"id":[{"id":"10.13039\/100010146","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Human Mutation"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1002\/humu.23904","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T08:34:39Z","timestamp":1567067679000},"page":"169-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A rare heterozygous\n            <i>TREM2<\/i>\n            coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2"],"prefix":"10.1155","volume":"41","author":[{"given":"Meliha","family":"Karsak","sequence":"first","affiliation":[{"name":"Center for Molecular Neurobiology (ZMNH)University Medical Center Hamburg\u2010Eppendorf (UKE)Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Glebov","sequence":"additional","affiliation":[{"name":"Department of NeurologyUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Scheffold","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology (ZMNH)University Medical Center Hamburg\u2010Eppendorf (UKE)Hamburg Germany"},{"name":"Institute of Pharmacology and ToxicologyUniversity of UlmUlm Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical FacultyUniversity of CologneCologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Kawalia","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical FacultyUniversity of CologneCologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rading","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology (ZMNH)University Medical Center Hamburg\u2010Eppendorf (UKE)Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and PsychotherapyUniversit\u00e4tsklinikum Erlangen and Friedrich\u2010Alexander Universit\u00e4t Erlangen\u2010N\u00fcrnbergErlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of PsychiatryCharit\u00e9 University MedicineBerlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Diez\u2010Fairen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Movement Disorders UnitsUniversity Hospital Mutua de TerrassaTerrassa Barcelona Spain"},{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatua TerrassaUniversity Hospital M\u00fatua de TerrassaTerrassa Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutz","family":"Fr\u00f6lich","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty MannheimUniversity of HeidelbergMannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"H\u00fcll","sequence":"additional","affiliation":[{"name":"Center for Psychiatry, Clinic for Geriatric Psychiatry and Psychotherapy Emmendingen and Department of Psychiatry and PsychotherapyUniversity of FreiburgFreiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Wiltfang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and PsychotherapyUniversity Medical Center G\u00f6ttingenG\u00f6ttingen Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Scherer","sequence":"additional","affiliation":[{"name":"Department of Primary Medical CareUniversity Medical Center Hamburg\u2010EppendorfHamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffi","family":"Riedel\u2010Heller","sequence":"additional","affiliation":[{"name":"Institute of Social Medicine, Occupational Health and Public HealthUniversity of LeipzigLeipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Heneka","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)Bonn Germany"},{"name":"Division of Infectious Diseases and Immunology, Department of MedicineUniversity of Massachusetts Medical SchoolWorcester Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Fliessbach","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sharaf","sequence":"additional","affiliation":[{"name":"Center for Molecular Neurobiology (ZMNH)University Medical Center Hamburg\u2010Eppendorf (UKE)Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Thiele","sequence":"additional","affiliation":[{"name":"Cologne Center for Genomics (CCG)University of CologneCologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Lennarz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and PsychotherapyUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)Bonn Germany"},{"name":"Department of Psychiatry and Psychotherapy, Medical FacultyUniversity of CologneCologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Maier","sequence":"additional","affiliation":[{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Kubisch","sequence":"additional","affiliation":[{"name":"Institute of Human GeneticsUniversity Medical Center Hamburg\u2010EppendorfHamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Ignatova","sequence":"additional","affiliation":[{"name":"Institute for Biochemistry and Molecular BiologyUniversity of HamburgHamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"N\u00fcrnberg","sequence":"additional","affiliation":[{"name":"Cologne Center for Genomics (CCG)University of CologneCologne Germany"},{"name":"Center for Molecular Medicine Cologne (CMMC)University of CologneCologne Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Movement Disorders UnitsUniversity Hospital Mutua de TerrassaTerrassa Barcelona Spain"},{"name":"Fundaci\u00f3 Doc\u00e8ncia i Recerca M\u00fatua TerrassaUniversity Hospital M\u00fatua de TerrassaTerrassa Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4678-2912","authenticated-orcid":false,"given":"Jochen","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of NeurologyUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-763X","authenticated-orcid":false,"given":"Alfredo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical FacultyUniversity of CologneCologne Germany"},{"name":"Department of Neurodegenerative Diseases and Geriatric PsychiatryUniversity of BonnBonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,15]]},"reference":[{"key":"e_1_2_9_1_2_1","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a002139"},{"key":"e_1_2_9_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.07.001"},{"key":"e_1_2_9_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.12.018"},{"key":"e_1_2_9_1_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.2.168"},{"key":"e_1_2_9_1_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0479-9"},{"key":"e_1_2_9_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.06.005"},{"key":"e_1_2_9_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr400514h"},{"key":"e_1_2_9_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14039"},{"key":"e_1_2_9_1_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016852"},{"key":"e_1_2_9_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu277"},{"key":"e_1_2_9_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_9_1_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126321"},{"key":"e_1_2_9_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.09.007"},{"key":"e_1_2_9_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0191-4"},{"key":"e_1_2_9_1_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009093"},{"key":"e_1_2_9_1_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000210388"},{"key":"e_1_2_9_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.08.008"},{"key":"e_1_2_9_1_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418155112"},{"key":"e_1_2_9_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.12.009"},{"key":"e_1_2_9_1_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_2_9_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_9_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.09.017"},{"key":"e_1_2_9_1_24_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030027"},{"key":"e_1_2_9_1_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12264"},{"key":"e_1_2_9_1_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000500"},{"key":"e_1_2_9_1_27_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77983"},{"key":"e_1_2_9_1_28_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M608437200"},{"key":"e_1_2_9_1_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu372"},{"key":"e_1_2_9_1_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20750"},{"key":"e_1_2_9_1_31_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201707672"},{"key":"e_1_2_9_1_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"e_1_2_9_1_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-018-0051-1"},{"key":"e_1_2_9_1_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3916"},{"key":"e_1_2_9_1_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-016-0367-7"},{"key":"e_1_2_9_1_36_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041611"},{"key":"e_1_2_9_1_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-018-0072-1"},{"key":"e_1_2_9_1_38_1","doi-asserted-by":"publisher","DOI":"10.2741\/3594"},{"key":"e_1_2_9_1_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00018"},{"key":"e_1_2_9_1_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.10.004"},{"key":"e_1_2_9_1_41_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R115.704981"},{"key":"e_1_2_9_1_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3920"},{"key":"e_1_2_9_1_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.517540"},{"key":"e_1_2_9_1_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.03.008"}],"container-title":["Human Mutation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/humu.23904","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/humu.23904","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/humu.23904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T16:54:02Z","timestamp":1672332842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/humu.23904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,15]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/humu.23904"],"URL":"https:\/\/doi.org\/10.1002\/humu.23904","archive":["Portico"],"relation":{},"ISSN":["1059-7794","1098-1004"],"issn-type":[{"value":"1059-7794","type":"print"},{"value":"1098-1004","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,15]]},"assertion":[{"value":"2019-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}