{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:27:14Z","timestamp":1791142034179,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T00:00:00Z","timestamp":1234137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The purpose of the present study was to examine the relationship between drug\u2010induced parkinsonism (DIP) and subjective non\u2010motor cognitive impairments in schizophrenia by performing comprehensive assessments of extrapyramidal side effects (EPS) and the subjective cognitive\u2010perceptual functioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010one outpatients with schizophrenia were evaluated for DIP and other EPS. Subjective cognitive\u2010perceptual dysfunction was comprehensively assessed using the Frankfurt Complaint Questionnaire (FCQ). To examine the association between DIP and non\u2010motor cognitive\u2010perceptual dysfunction, Pearson's partial correlation analysis was performed between the FCQ scores and the severity of DIP, controlling for relevant variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis revealed that the severity of DIP had a significant correlation with the total FCQ score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In phenomenological subscales, the severity of DIP showed significant correlations with \u201cdeterioration of discrimination,\u201d \u201cpsychomotor disorder,\u201d \u201cperceptual disorder,\u201d \u201ccognitive floating,\u201d and \u201cautomatic behavior disorder\u201d (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of our study suggest that DIP is significantly associated with a wide range of subjective non\u2010motor cognitive impairments. Clinicians should be careful of the appearance of DIP and the associated non\u2010motor cognitive\u2010perceptual symptoms, which may cause considerable distress and reduce the quality of life in an already vulnerable group of patients. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1009","type":"journal-article","created":{"date-parts":[[2009,2,9]],"date-time":"2009-02-09T09:02:32Z","timestamp":1234170152000},"page":"129-133","source":"Crossref","is-referenced-by-count":14,"title":["Non\u2010motor cognitive\u2010perceptual dysfunction associated with drug\u2010induced parkinsonism"],"prefix":"10.1002","volume":"24","author":[{"given":"Jong\u2010Hoon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hee\u2010Jung","family":"Byun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,9]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_1_3_1","first-page":"2317","volume-title":"Comprehensive textbook of psychiatry","author":"Ballenger JC","year":"2000"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.154.5.672"},{"key":"e_1_2_1_5_1","first-page":"754","article-title":"Manual of Kyung Hee Frankfurt Beschwerde Fragebogen","volume":"34","author":"Chang HI","year":"1995","journal-title":"J Korean Neuropsychiatr Assoc"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21596"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02274900"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1999.tb05990.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(91)90028-K"},{"key":"e_1_2_1_10_1","unstructured":"GuyW.1976.ECDEU Assessment Manual for Psychopharmacology Revised (DHEW Publ NoADM 76\u2013338)U.S. Department of Health Education and Welfare Public Health Service Alcohol Drug Abuse and Mental Health Administration NIMH Psychopharmacology Research Branch Division of Extramural Research Programs Rockville MD"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.918"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.188.2.192"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-005-0633-3"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.5.1.61"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10255"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20639"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-9338(99)80722-6"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1977.tb00174.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2002.33487"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3182(00)71169-8"},{"key":"e_1_2_1_21_1","first-page":"2276","volume-title":"Comprehensive Textbook of Psychiatry","author":"Meyer JM","year":"2000"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(01)00110-9"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511544163"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00167-X"},{"issue":"7","key":"e_1_2_1_25_1","first-page":"VII2","article-title":"The natural history of Parkinson's disease","volume":"253","author":"Poewe W","year":"2006","journal-title":"J Neurol"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2003.08.011"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-198904000-00001"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1970.tb02066.x"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81128-9"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-198300061-00004"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216010-00003"},{"key":"e_1_2_1_32_1","first-page":"13","article-title":"Behavioral toxicity of antipsychotic drugs","volume":"48","author":"Van Putten T","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1981.01780270073010"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.141.1.16"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1978.01770280087009"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(01)00161-X"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1648-y"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.1009","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.1009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T22:38:53Z","timestamp":1699915133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.1009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,9]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["10.1002\/hup.1009"],"URL":"https:\/\/doi.org\/10.1002\/hup.1009","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,9]]}}}