{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:38:24Z","timestamp":1789997904109,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T00:00:00Z","timestamp":1259280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to explore the possibility of the use of Virtual Reality Functional Skills Assessment (VRFSA) in a future regular clinical trial, as well as to report a preliminary result about effectiveness of atypical antipsychotics to social competence in schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed the VRFSA that measured subjects' performances automatically and used analogue scale rather than Likert scale. Twenty\u2010four female patients with paranoid schizophrenia and 15 healthy females were recruited. This was a 6\u2010week, randomized, open\u2010label, and flexible dose study, and 2 treatments (baseline versus post\u2010treatment)\u2009\u00d7\u20092 skills phases (receptive versus expressive)\u2009\u00d7\u20092 patient groups (aripiprazole versus risperidone) analysis of variance was used in the final analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant difference in the VRFAS between the patients and the healthy subjects (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Eighteen patients were included in the final analysis. We found larger treatment effect than those found in previous studies, and significant treatment\u2009\u00d7\u2009skills phase\u2009\u00d7\u2009group interaction effect on the VRFAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the VRFAS is strongly sensitive to changes in social competence and thus especially beneficial in short\u2010term clinical trials. In addition, atypical antipsychotics can improve social competence and differentially improve receptive skills and expressive skills in schizophrenia. Copyright \u00a9 2009 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1071","type":"journal-article","created":{"date-parts":[[2009,11,28]],"date-time":"2009-11-28T04:01:19Z","timestamp":1259380879000},"page":"619-627","source":"Crossref","is-referenced-by-count":20,"title":["Improvement in social competence in patients with schizophrenia: a pilot study using a performance\u2010based measure using virtual 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