{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:46:35Z","timestamp":1786977995891,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T00:00:00Z","timestamp":1312761600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to compare maternal and neonatal outcome of opioid\u2010dependent women maintained on buprenorphine or methadone throughout pregnancy in a randomized double\u2010blind double\u2010dummy clinical trial (CT) with a comparison group undergoing a structured standard protocol (SP) at the Medical University of Vienna, Austria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      One hundred and fourteen subjects were included in the analysis, with 77 in SP (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200951 methadone,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926 buprenorphine), and 37 in CT (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200919 methadone,\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200918 buprenorphine), comparing maternal concomitant consumption during third trimester, demographic birth data, duration of treatment for neonatal abstinence syndrome (NAS), morphine dose for NAS treatment and length of hospital stay (LOS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both study groups yielded healthy neonates with no significant demographic differences and equivalently low rates of positive maternal urine toxicologies. However, NAS parameters were significantly better in CT regarding total medication dose administered to neonates (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and LOS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015). Superior results were achieved in buprenorphine compared with methadone\u2010exposed neonates regarding gestational age at birth (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003), birth weight (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011), total morphine dose administered (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008), NAS treatment duration (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) and LOS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Comparably favorable outcome for mothers and infants and efficacy and safety of opioid medications were shown in both treatment approaches. Neonatal care could benefit from transferring successful CT procedures into clinical practice. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hup.1224","type":"journal-article","created":{"date-parts":[[2011,8,8]],"date-time":"2011-08-08T05:33:27Z","timestamp":1312781607000},"page":"412-421","source":"Crossref","is-referenced-by-count":41,"title":["Impact of treatment approach on maternal and neonatal outcome in pregnant opioid\u2010maintained women"],"prefix":"10.1002","volume":"26","author":[{"given":"Verena","family":"Metz","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna<sup>\u2020<\/sup>  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhold","family":"Jagsch","sequence":"additional","affiliation":[{"name":"Faculty of Psychology Vienna University  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Ebner","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Medical University of Vienna  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"W\u00fcrzl","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna<sup>\u2020<\/sup>  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pribasnig","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna<sup>\u2020<\/sup>  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantin","family":"Aschauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna<sup>\u2020<\/sup>  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Medical University of Vienna<sup>\u2020<\/sup>  Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,8,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1542\/peds.101.6.1079","article-title":"Neonatal withdrawal","volume":"101","author":"American Academy of Pediatrics Committee on Drugs","year":"1998","journal-title":"Pediatrics"},{"key":"e_1_2_10_3_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders\u2014DSM\u2010IV","author":"American Psychiatric Association","year":"1994"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/S0002-9378(03)00520-9"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2010.03120.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(02)02387-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02073.x"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.08.024"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00846549"},{"key":"e_1_2_10_10_1","first-page":"19","article-title":"Assessment and treatment of abstinence in the infant of the drug dependent mother","volume":"12","author":"Finnegan LP","year":"1975","journal-title":"International J Clin Pharm Biopharmacy"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95811411.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007370050014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000052040"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1999.94913376.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95223910.x"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2006.01321.x"},{"issue":"6","key":"e_1_2_10_17_1","first-page":"11","article-title":"Prospective study of favorable factors in follow\u2010up of drug addicted patients\u2014apropos of 257 patients of the Cassini Center in Paris","volume":"26","author":"Goeb JL","year":"2000","journal-title":"Encephale"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1003462"},{"key":"e_1_2_10_19_1","volume-title":"European Addiction Severity Index (Europ\u2010ASI)\u2014Manual f\u00fcr Training und Durchf\u00fchrung","author":"Gsellhofer B","year":"1999"},{"issue":"9","key":"e_1_2_10_20_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2807\/ese.14.09.19142-en","article-title":"Drug use and pregnancy\u2014challenges for public health","volume":"14","author":"Gyarmathy VA","year":"2009","journal-title":"Euro Surveill"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900013870"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02237.x"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2004.11.013"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005359"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsat.2007.10.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601110770"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2008.01.025"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8545(05)70362-4"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-16419"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.041"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1385\/1-59259-282-1:125"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6909.2009.01006.x"},{"issue":"4","key":"e_1_2_10_33_1","first-page":"140","article-title":"Subjektive evaluationskriterien in der psychiatrischen versorgung\u2014erhebungsmethoden f\u00fcr forschung und praxis. [Subjective evaluation criteria in psychiatric care\u2014methods of assessment for research and general practice]. [German]","volume":"22","author":"Priebe S","year":"1999","journal-title":"Psychiatrische Praxis (Berlin)"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-19054"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-0994-0"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2003.00245.x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1465-3362.2009.00076.x"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2008.10.012"},{"issue":"2","key":"e_1_2_10_39_1","first-page":"129","article-title":"Treatment of a pregnant opiate addict with oral methadone","volume":"29","author":"Sullivan RD","year":"1972","journal-title":"Ariz Med"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/10550881003684814"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000284683"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e31817e6105"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.2008.02283.x"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.1224","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.1224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:37:57Z","timestamp":1695476277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.1224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["10.1002\/hup.1224"],"URL":"https:\/\/doi.org\/10.1002\/hup.1224","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}