{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:17:57Z","timestamp":1789949877220,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T00:00:00Z","timestamp":1312502400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The STISIM driving simulator is widely used. To enhance its usefulness in pharmacological research, a calibration study was performed to test a standardized highway driving test scenario after administration of three different dosages of alcohol and placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010seven healthy young adults (14 men and 13 women; mean age (SD)\u2009=\u200922.8 (1.4)) participated in this randomized, single\u2010blind crossover trial. Subjects received alcohol to gain a blood alcohol concentration (BAC) of 0.05%, 0.08%, and 0.11%, or placebo\u2013alcohol. In each condition, subjects completed a 100\u2010km highway driving simulator test. The standard deviation of lateral position, the weaving of the car, was the primary parameter of the test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Alcohol produced dose\u2010dependent driving impairment. Standard deviation of lateral position and standard deviation of speed were significantly increased relative to placebo (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Subjective driving assessments were in line with the objective driving measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The STISIM highway driving simulator test is able to differentiate dose\u2010dependent impairment after administration of alcohol. The highway driving test scenario is suitable for future psychopharmacological research. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1226","type":"journal-article","created":{"date-parts":[[2011,8,5]],"date-time":"2011-08-05T13:24:19Z","timestamp":1312550659000},"page":"434-439","source":"Crossref","is-referenced-by-count":82,"title":["Effects of alcohol on highway driving in the STISIM driving simulator"],"prefix":"10.1002","volume":"26","author":[{"given":"Monique A. 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