{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T07:33:15Z","timestamp":1768462395559,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The goal of this study was to investigate the safety and efficacy in preventing relapse of a mood episode in recently manic or mixed episode patients with bipolar I disorder stabilized with aripiprazole and divalproex combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomized, 24\u2010week, double\u2010blind, placebo\u2010controlled multicenter study enrolled patients from 23 centers in Korea. Patients with bipolar I disorder who had manic or mixed episode entered a 6\u2010week open\u2010label stabilization phase. After meeting stabilization criteria, 83 patients were randomly assigned to placebo\u2009+\u2009divalproex or aripiprazole\u2009+\u2009divalproex treatment group for the 24\u2010week, double\u2010blind maintenance phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the 6\u2010month double\u2010blind treatment, the time to relapse of any mood episode in the aripiprazole group was longer than the placebo group, but the difference did not reach statistical significance (<jats:italic>p<\/jats:italic>\u2009=\u20090.098). After controlling for mean divalproex level, the time to depressive episode relapse in the aripiprazole group was longer than those in the placebo group (<jats:italic>p<\/jats:italic>\u2009=\u20090.029). Weight gain (\u22657% increase) occurred in 22.5% aripiprazole group and 18.6% placebo group (<jats:italic>p<\/jats:italic>\u2009=\u20090.787).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, relapse of mood episode occurred fewer and later for aripiprazole with divalproex treatment than divalproex monotherapy, but the differences were not statistically significant. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1240","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T13:07:01Z","timestamp":1322917621000},"page":"543-553","source":"Crossref","is-referenced-by-count":33,"title":["Aripiprazole plus divalproex for recently manic or mixed patients with bipolar I disorder: a 6\u2010month, randomized, placebo\u2010controlled, double\u2010blind maintenance trial"],"prefix":"10.1002","volume":"26","author":[{"given":"Young Sup","family":"Woo","sequence":"first","affiliation":[{"name":"Department of Psychiatry, College of Medicine The Catholic University of Korea Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u2010Myong","family":"Bahk","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine The Catholic University of Korea Seoul South 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