{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T20:40:36Z","timestamp":1741984836661,"version":"3.38.0"},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,12,2]],"date-time":"2011-12-02T00:00:00Z","timestamp":1322784000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the effectiveness of amisulpride in acute (up to 8\u2009weeks) and maintenance (week 8 to 12\u2009months) phases of a 12\u2010month course of treatment in a heterogeneous group of patients with schizophrenia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 12\u2010month, open\u2010label clinical trial with flexible doses of amisulpride among 129 Korean patients with schizophrenia. The Positive and Negative Symptom Scale (PANSS) and several other scales measuring efficacy and tolerability were analyzed during the acute and maintenance phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The completion rates were 78.3% by week 8 and 55.8% by month 12. Total PANSS scores and scores on the negative\u2010symptom and general\u2010symptom subscales improved significantly during both acute and maintenance periods, but scores on the positive\u2010symptom subscale improved only during the acute phase. Improvement during both treatment phases was significant in all other scales except for the Drug Attitude Inventory. The negative\u2010symptom and mixed\u2010symptom groups showed significant improvement in the PANSS negative subscale, the Clinical Global Impression scale, and the Global Assessment of Functioning during the maintenance period. Hyperprolactinemia and related events were commonly reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study demonstrated the significant effectiveness and a good safety profile of amisulpride for treating acute and 12\u2010month phases of schizophrenia under natural conditions. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1246","type":"journal-article","created":{"date-parts":[[2011,12,3]],"date-time":"2011-12-03T13:28:56Z","timestamp":1322918936000},"page":"568-577","source":"Crossref","is-referenced-by-count":5,"title":["The acute and long\u2010term effectiveness of amisulpride in patients with schizophrenia: results of a 12\u2010month open\u2010label prospective follow\u2010up study"],"prefix":"10.1002","volume":"26","author":[{"given":"Yong Min","family":"Ahn","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Science and Institute of Human Behavioral Medicine Seoul National University College of Medicine, Seoul National University Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Eulji University School of Medicine, Eulji General Hospital 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