{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T01:27:48Z","timestamp":1791336468002,"version":"4.3.1"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,12,8]],"date-time":"2011-12-08T00:00:00Z","timestamp":1323302400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation\u2010induced impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty healthy volunteers were administered either a 5\u2010mg daily dose of donepezil or placebo for 14\u201317\u2009days, in a double\u2010blind parallel group design, then underwent either 24\u2009h sleep deprivation or a normal night of sleep in non\u2010blinded crossover, and were subsequently tested on a battery of cognitive tasks designed to measure different components of memory and executive function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sleep deprivation selectively impaired performance on several memory tasks whilst also impairing non\u2010memory function on these tasks. Performance on other tasks was spared. Despite partially reversing the decline in subjective alertness associated with sleep deprivation, treatment with donepezil failed to significantly reverse the decline in cognitive performance on any of the tasks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results demonstrate the sensitivity of certain tests, particularly those that measure memory function, to cognitive impairment after sleep deprivation. The inability of donepezil to reverse this performance decline suggests that the sleep deprivation model of cognitive impairment may not be suitable for detecting pro\u2010cognitive effects of cholinergic augmentation. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1248","type":"journal-article","created":{"date-parts":[[2011,12,9]],"date-time":"2011-12-09T01:20:51Z","timestamp":1323393651000},"page":"578-587","source":"Crossref","is-referenced-by-count":24,"title":["Effects of donepezil on cognitive performance after sleep deprivation"],"prefix":"10.1002","volume":"26","author":[{"given":"Chris M.","family":"Dodds","sequence":"first","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T.","family":"Bullmore","sequence":"additional","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"},{"name":"Brain Mapping Unit, Department of Psychiatry University of Cambridge  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Henson","sequence":"additional","affiliation":[{"name":"MRC Cognition and Brain Sciences Unit  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren","family":"Christensen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Pharmacokinetics Lundbeck Pharmaceuticals  Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Miller","sequence":"additional","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences Birkbeck, University of London  UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Dewit","sequence":"additional","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phil","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep J.","family":"Nathan","sequence":"additional","affiliation":[{"name":"Clinical Unit Cambridge, Medicines Discovery &amp; Development GlaxoSmithKline R&amp;D  Cambridge UK"},{"name":"Brain Mapping Unit, Department of Psychiatry University of Cambridge  UK"},{"name":"School of Psychology and Psychiatry Monash University  Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2008.00661.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881104040248"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000155822.51962.b4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh011"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001190.pub2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0007-04.2004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283052cf7"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2005.12.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1523\/JNEUROSCI.0733-08.2008","article-title":"Lapsing during sleep deprivation is associated with distributed changes in brain activation","volume":"28","author":"Chee MW","year":"2008","journal-title":"J Neurosci"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2004.11.029"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4045-08.2008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0906-06.2006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.8.999"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02508-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051272"},{"key":"e_1_2_7_17_1","first-page":"253","article-title":"Sustained attention performance during sleep deprivation: evidence of state instability","volume":"139","author":"Doran SM","year":"2001","journal-title":"Arch Ital Biol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.83805"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/35001068"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2001.00245.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNN.0b013e3181799df1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.1319"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000077733"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e3181630b81"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079902125001029"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(98)00063-8"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110391832"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-0043-2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cogbrainres.2003.10.019"},{"key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/713755870","article-title":"Sleep loss and temporal memory","volume":"53","author":"Harrison Y","year":"2000","journal-title":"Q J Exp Psychol A"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.676"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017259"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2007.00583.x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100753"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1037\/0096-3445.118.2.126"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9280.02456"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.2307\/2533558"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.205"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207450108986529"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06719.x"},{"key":"e_1_2_7_41_1","first-page":"342","article-title":"Effectiveness of donepezil on several cognitive functions in patients with Alzheimer's disease over 12\u2009months","volume":"16","author":"Lopez\u2010Pousa S","year":"2001","journal-title":"Neurologia"},{"issue":"33","key":"e_1_2_7_42_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tics.2006.12.003","article-title":"Associative memory and the medial temporal lobes","volume":"11","author":"Mayes A","year":"2007","journal-title":"Trends in Cognitive Sciences"},{"key":"e_1_2_7_43_1","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1523\/JNEUROSCI.23-29-09687.2003","article-title":"Sleep deprivation causes behavioral, synaptic, and membrane excitability alterations in hippocampal neurons","volume":"23","author":"McDermott CM","year":"2003","journal-title":"J Neurosci"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1960.03590090003002"},{"key":"e_1_2_7_45_1","unstructured":"NelsonHE.1982.The National Adult Reading Test (NART): Test Manual: NFER\u2010Nelson."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2869.2005.00442.x"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(94)00098-A"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051207"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.02.009"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-7-26"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00091-8"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1998.0460s1007.x"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610202008372"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02708-6"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2007.02049.x"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2869.2000.00225.x"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn073"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0080017"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.20076"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.1.123"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1006\/ccog.1996.0008"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.1248","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.1248","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T06:13:28Z","timestamp":1700547208000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.1248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1002\/hup.1248"],"URL":"https:\/\/doi.org\/10.1002\/hup.1248","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}