{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T13:26:27Z","timestamp":1749561987870},"reference-count":51,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,11,15]],"date-time":"2011-11-15T00:00:00Z","timestamp":1321315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the safety and efficacy of olanzapine monotherapy in treatment\u2010resistant bipolar mania.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Subjects (<jats:italic>n<\/jats:italic>\u2009=\u200918) who were acutely manic, did not respond to lithium, anticonvulsants, and neuroleptics, and\/or had intolerable side effects to them in previous manic episodes were openly treated with olanzapine monotherapy (5\u201340\u2009mg\/d) for 12\u2009weeks. The primary and secondary outcomes included the change from baseline to endpoint in Young Mania Rating Scale (YMRS) total score, Clinical Global Impression for Bipolar Disorder\u2010Severity Scale (CGI\u2010S), 17\u2010item Hamilton Depression Rating Scale (HAM\u2010D) and Positive and Negative Syndrome Scale (PANSS), and response and remission rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean change in YMRS total score from baseline to endpoint was \u221223.3\u2009\u00b1\u20098.4 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Fifteen (88.5%) patients achieved response (\u226550% reduction in YMRS total score) and 14 (77.8%) achieved remission (YMRS total score \u22649 at endpoint). Mean changes from baseline to endpoint in CGI\u2010S for mania and PANSS total score were significant, but not the changes in HAM\u2010D total score or CGI\u2010S for depression. The most common adverse events were sedation, self\u2010reported weight gain, \u22657% increase in body weight, dizziness, and akathisia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary results suggest that olanzapine monotherapy is effective and relatively safe in patients with treatment\u2010resistant bipolar mania. Randomized, double\u2010blind, placebo\u2010controlled study is warranted. Copyright \u00a9 2011 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.1249","type":"journal-article","created":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T19:41:14Z","timestamp":1321472474000},"page":"588-595","source":"Crossref","is-referenced-by-count":5,"title":["Safety and efficacy of olanzapine monotherapy in treatment\u2010resistant bipolar mania: a 12\u2010week open\u2010label study"],"prefix":"10.1002","volume":"26","author":[{"given":"Jun","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Mood Disorders, Shanghai Mental Health Center Shanghai Jiao Tong University, School of Medicine  Shanghai China"},{"name":"Department of Psychiatry, Mood Disorders Program Case Western Reserve University School of Medicine, University Hospitals Case Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Muzina","sequence":"additional","affiliation":[{"name":"Department of 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