{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T18:11:25Z","timestamp":1775239885863,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2001,1,25]],"date-time":"2001-01-25T00:00:00Z","timestamp":980380800000},"content-version":"vor","delay-in-days":55,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inhibitors of monoamine oxidase A (MAO\u2010A) but not MAO\u2010B stimulate the activity of pineal serotonin <jats:italic>N<\/jats:italic>\u2010acetyltransferase (AANAT) in the adult rat pineal leading to increased formation of <jats:italic>N<\/jats:italic>\u2010acetyl serotonin (NAS) and melatonin (MEL). The pineal gland of the neonatal rat has AANAT activity, but the second enzyme in melatonin biosynthesis, HIOMT (hydroxyindole\u2010<jats:italic>O<\/jats:italic>\u2010methyltransferase) converting NAS to MEL, is absent during the first week of neonatal life. In this study we examined the effects of acute clorgyline treatment <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>, on pineal indoles over the first month of neonatal life. The results show that clorgyline stimulates NAS production by pineal both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> from day five on with a marked increase between day 14 and day 21. In contrast, MEL is not increased until day 21, with a sharp rise thereafter. Copyright \u00a9 2000 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/hup.217","type":"journal-article","created":{"date-parts":[[2002,9,11]],"date-time":"2002-09-11T01:02:04Z","timestamp":1031706124000},"page":"589-593","source":"Crossref","is-referenced-by-count":1,"title":["Ontogenetic effects of MAO\u2010A inhibition on rat pineal <i>n<\/i>\u2010acetylserotonin and melatonin during the first month of neonatal life"],"prefix":"10.1002","volume":"15","author":[{"given":"Gregory F","family":"Oxenkrug","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pura J","family":"Requintina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Yuwiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,1,25]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/401753"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.8.2208"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1972.tb01458.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00338980"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(81)90644-5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(79)90848-5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01251917"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01260919"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.1988.tb00772.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(76)90083-6"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-99-3-840"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(98)00114-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/258435a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1977.233.3.E141"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000122210"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.56.2.515"}],"container-title":["Human Psychopharmacology: Clinical and Experimental"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhup.217","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hup.217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T04:02:10Z","timestamp":1695873730000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hup.217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":16,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1002\/hup.217"],"URL":"https:\/\/doi.org\/10.1002\/hup.217","archive":["Portico"],"relation":{},"ISSN":["0885-6222","1099-1077"],"issn-type":[{"value":"0885-6222","type":"print"},{"value":"1099-1077","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}