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This study employed the \u2018tilt aftereffect\u2019 paradigm to operationalise the function of orientation\u2010selective neurons among ecstasy consumers and controls as a means of investigating the role of reduced serotonin on visual orientation processing. The magnitude of the tilt aftereffect reflects the extent of lateral inhibition between orientation\u2010selective neurons and is elicited to both \u2018real\u2019 contours, processed in visual cortex area V1, and illusory contours, processed in V2. The magnitude of tilt aftereffect to both contour types was examined among 19 ecstasy users (6 ecstasy only; 13 ecstasy\u2010plus\u2010cannabis users) and 23 matched controls (9 cannabis\u2010only users; 14 drug\u2010naive). Ecstasy users had a significantly greater tilt magnitude than non\u2010users for real contours (Hedge's<jats:italic>g<\/jats:italic>\u2009=\u20090.63) but not for illusory contours (<jats:italic>g<\/jats:italic>\u2009=\u20090.20). These findings provide support for literature suggesting that residual effects of ecstasy (and reduced serotonin) impairs lateral inhibition between orientation\u2010selective neurons in V1, which however suggests that ecstasy may not substantially affect this process in V2. Multiple studies have now demonstrated ecstasy\u2010related deficits on basic visual functions, including orientation and motion processing. Such low\u2010level effects may contribute to the impact of ecstasy use on neuropsychological tests of visuospatial function. 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