{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:18:22Z","timestamp":1790738302001,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T00:00:00Z","timestamp":1339977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to assess the acute effect of intranasally administered oxytocin (OT) on subjective states, cardiovascular, and endocrine parameters in healthy volunteers who inhaled 7.5% CO<jats:sub>2<\/jats:sub>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five subjects were allocated into three matched groups of subjects who received 24\u2009international units (IU) of OT, 2\u2009mg of lorazepam (LZP), or placebo (PL). The challenge consisted of medical air inhalation for 20\u2009min, 10\u2009min of rest, and CO<jats:sub>2<\/jats:sub> 7.5% inhalation for 20\u2009min. Subjective effects were evaluated by self\u2010assessment scales; heart rate, blood pressure, skin conductance, and salivary cortisol were also measured. Assessments were performed at four time points: (i) baseline (\u221215\u2009min); (ii) post\u2010air inhalation (90\u2009min); (iii) post\u2010CO<jats:sub>2<\/jats:sub> inhalation (120\u2009min), and (iv) post\u2010test (160\u2009min).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CO<jats:sub>2<\/jats:sub> inhalation significantly increased the anxiety score in the PL group compared with the post\u2010air measurement but not in the OT or LZP groups. The LZP reduced anxiety after medical air inhalation. Other parameters evaluated were not affected by OT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>OT, as well as LZP, prevented CO<jats:sub>2<\/jats:sub>\u2010induced anxiety, suggesting that this hormone has anxiolytic properties. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2237","type":"journal-article","created":{"date-parts":[[2012,6,18]],"date-time":"2012-06-18T19:21:12Z","timestamp":1340047272000},"page":"378-385","source":"Crossref","is-referenced-by-count":38,"title":["Oxytocin interference in the effects induced by inhalation of 7.5% CO<sub>2<\/sub> in healthy volunteers"],"prefix":"10.1002","volume":"27","author":[{"given":"Danielle Chaves Gomes","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Behavior, Faculty of Medicine of Ribeir\u00e3o Preto, and National Institute for Translacional Medicine (INCT\u2010TM, CNPq) University of S\u00e3o Paulo  Ribeir\u00e3o Preto Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Hortes N.","family":"Chagas","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Faculty of Medicine of Ribeir\u00e3o Preto, and 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