{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T03:02:48Z","timestamp":1792206168833,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Psychopharmacology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antihistamines with strong sedative\u2013hypnotic properties are frequently prescribed for insomnia secondary to allergy, but the potential risks of such administration have not been fully elucidated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and methods<\/jats:title><jats:p>This randomized, double\u2010blind, placebo\u2010controlled crossover study was conducted to evaluate next\u2010day sleepiness and psychomotor performance following the administration of antihistamines. Twenty\u2010two healthy male participants participated in four drug administration sessions with more than a 1\u2010week interval between the sessions. Either zolpidem 10\u2009mg, or diphenhydramine 50\u2009mg, or ketotifen 1\u2009mg, or a placebo was administered before sleep, and polysomnography was conducted to evaluate sleep. In the morning and afternoon of the day after administration, the participants were evaluated for subjective sleepiness, objective sleepiness, and psychomotor performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The antihistamines with high blood\u2013brain barrier\u2010crossing efficiency were significantly associated with sleepiness and psychomotor performance decline the next day. Ketotifen showed the strongest carryover effect, followed by diphenhydramine. Compared with the placebo, no significant carryover effect was observed with zolpidem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that the risk\u2013benefit balance should be considered in the ready use of antihistamines that easily cross the blood\u2013brain barrier for alleviating secondary insomnia associated with allergies. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hup.2244","type":"journal-article","created":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T04:25:43Z","timestamp":1342671943000},"page":"428-436","source":"Crossref","is-referenced-by-count":30,"title":["Carryover effect on next\u2010day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: a randomized controlled trial"],"prefix":"10.1002","volume":"27","author":[{"given":"Yasuko","family":"Katayose","sequence":"first","affiliation":[{"name":"Department of Psychophysiology National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Aritake","sequence":"additional","affiliation":[{"name":"Department of Somnology Tokyo Medical University and Japan Society for the Promotion of Science  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Department of Psychophysiology National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minori","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Psychophysiology National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Psychophysiology National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyohisa","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Japan Foundation for Neuroscience and Mental Health  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Mishima","sequence":"additional","affiliation":[{"name":"Department of Psychophysiology National Institute of Mental Health, National Center of Neurology and Psychiatry  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"International Classification of Sleep Disorders: Diagnostic and Coding Manual","author":"AASM","year":"2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1986.tb02962.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/20.4.258"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n1005"},{"key":"e_1_2_8_6_1","first-page":"884","article-title":"Comparative in vivo and in vitro regional selectivity of central omega (benzodiazepine) site ligands in inhibiting [3H]flumazenil binding in the rat central nervous system","volume":"263","author":"Benavides J","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X112660"},{"key":"e_1_2_8_8_1","volume-title":"Principles and Practice of Sleep Medicine","author":"Buysse D","year":"2011"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/9.4.519"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02325.x"},{"key":"e_1_2_8_11_1","first-page":"649","article-title":"Zolpidem, a novel nonbenzodiazepine hypnotic. 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